Evidence map›Paper›PMID 39609265›Full record

ArticleThe FEBS journal2025

Transition metal transporting P-type ATPases: terminal metal-binding domains serve as sensors for autoinhibitory tails.

Qiaoxia Hu, Oleg Sitsel, Viktoria Bågenholm, Christina Grønberg, Pin Lyu, Anna Sigrid Pii Svane, Kasper Røjkjær Andersen, Nick Stub Laursen, Gabriele Meloni, Poul Nissen and 4 more

Abstract read
In one paragraph

Article in The FEBS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qiaoxia HuDepartment of Biomedical Sciences, University of Copenhagen, Denmark.
Oleg SitselDepartment of Molecular Biology and Genetics, Aarhus University, Denmark.
Viktoria BågenholmDepartment of Biomedical Sciences, University of Copenhagen, Denmark.ORCID 0000-0001-8074-412X
Christina GrønbergDepartment of Biomedical Sciences, University of Copenhagen, Denmark.
Pin LyuDepartment of Biomedical Sciences, University of Copenhagen, Denmark.
Anna Sigrid Pii SvaneInterdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Denmark.
Kasper Røjkjær AndersenDepartment of Molecular Biology and Genetics, Aarhus University, Denmark.
Nick Stub LaursenDepartment of Molecular Biology and Genetics, Aarhus University, Denmark.
Gabriele MeloniDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
Poul NissenDepartment of Molecular Biology and Genetics, Aarhus University, Denmark.
Dennis W JuhlInterdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Denmark.ORCID 0000-0002-3416-5597
Jakob Toudahl NielsenInterdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Denmark.
Niels Chr NielsenInterdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Denmark.ORCID 0000-0003-2978-4366
Pontus GourdonDepartment of Biomedical Sciences, University of Copenhagen, Denmark.ORCID 0000-0002-8631-3539

Funding

Principles of selectivity and translocation in transition metal transporters, metallochaperones, and associated metalloproteinsR35GM128704 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Gabriele Meloni · 2018 to 2026
$3.5M
Agnes og Poul Friis FondAugustinus Fonden 16-1992Carlsbergfondet CF15-0542Carlsbergfondet CF21-0647China Scholarship CouncilCrafoordska Stiftelsen 20170818Crafoordska Stiftelsen 20180652Crafoordska Stiftelsen 20200739Crafoordska Stiftelsen 20220905Danmarks Frie Forskningsfond 3101-00303Danmarks Frie Forskningsfond 6108-00479Danmarks Frie Forskningsfond 9039-00273Danmarks Grundforskningsfond DNRF 59Fabrikant Vilhelm Pedersen og Hustrus LegatHartmann Fonden A29519Knut och Alice Wallenbergs Stiftelse 2015.0131Knut och Alice Wallenbergs Stiftelse 2020.0194Lundbeck Foundation R133-A12689Lundbeck Foundation R218-2016-1548Lundbeck Foundation R310-2018-3713Lundbeck Foundation R313-2019-774Lundbeck Foundation R346-2020-2019NIGMS NIH HHS R35 GM128704NIGMS NIH HHS R35GM128704Novo Nordisk Fonden NNF13OC0007471Novo Nordisk Fonden NNF18SA0034956Novo Nordisk Fonden NNF220C0075797Vera og Carl Johan Michaelsens LegatVetenskapsrådet 2016-04474Vetenskapsrådet 2022-01315
6 · The paper itself

Abstract

Copper is an essential micronutrient and yet is highly toxic to cells at elevated concentrations. P

Indexed as

Adenosine TriphosphatasesCopperP-type ATPasesBinding SitesCopper-Transporting ATPasesHumansModels, MolecularProtein BindingProtein DomainsAdenosine TriphosphatasesCopperCopper-Transporting ATPasesP-type ATPasesautoinhibitioncopper transportmetal‐binding domainsP‐type ATPasesregulation

Identifiers

PMID39609265
PMCPMC11970713

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.