ArticleCell reports2024
Individual differences in prelimbic neural representation of food and cocaine seeking.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Graph theory identifies altered prefrontal microcircuit organization in Shank3 mice, a mouse Model of autism.Cell reports · 2026Article
- Distinct ensembles in the prelimbic cortex track different measures of motivation for cocaine and water reinforcers.bioRxiv : the preprint server for biology · 2026Article
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- A shared ensemble in the prelimbic cortex links impulsivity and anxiety-like behavior.bioRxiv : the preprint server for biology · 2025Article
- Divergent prefrontal cortex circuits regulate cued food seeking under distinct metabolic or emotional states.Nature communications · 2025Article
- Using miniscopes and deep learning to compare neurobehavioral representations of psychostimulant and opioid self-administration.Addiction neuroscience · 2025Article
- Cell-type specific epigenetic and transcriptional mechanisms in substance use disorder.Frontiers in cellular neuroscience · 2025Review
- Miniscope Imaging of Nucleus Accumbens Neural Activity in Freely Behaving Rats: Virus Injection, Gradient Index Lens Implantation, Recording Strategies, and Analytical Methods.Current protocols · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The prelimbic cortex is involved in operant reward seeking. However, the precise nature of its activity patterns and whether/how they differ between different types of rewards are largely unknown. We use miniscope calcium imaging to observe prelimbic activity during both food and cocaine seeking in freely behaving mice. We find that neurobehavioral representations remain stable across days within individual mice. Unexpectedly, our data reveal significant individual differences: some mice display high similarity in their prelimbic cortex activity patterns for both food and cocaine seeking, while others show no such overlap. These findings suggest that individual differences in the neural mechanisms underlying food and cocaine seeking could be a critical factor to consider when developing future addiction treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.