Evidence map›Paper›PMID 39607745›Full record

ArticleMicrobiology (Reading, England)2024

Fluoride and gallein regulate polyphosphate accumulation in dental caries-associated

Subhrangshu Mandal, Beverly E Flood, Mark Lunzer, Dhiraj Kumar, Jake V Bailey

Abstract read
In one paragraph

Article in Microbiology (Reading, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Journal of medical microbiology · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Subhrangshu MandalDepartment of Earth & Environmental Sciences, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA.
Beverly E FloodDepartment of Earth & Environmental Sciences, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA.
Mark LunzerDepartment of Diagnostic and Biological Sciences, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA.
Dhiraj KumarDepartment of Diagnostic and Biological Sciences, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA.
Jake V BaileyDepartment of Earth & Environmental Sciences, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA.

Funding

The Unrecognized Role of Phosphate-accumulating Bacteria in Oral HealthR01DE027669 · NIDCR · UNIVERSITY OF MINNESOTA · PI BAILEY, JAKE, JONES, ROBERT SIMON · 2018 to 2022
$2.8M
NIDCR NIH HHS R01 DE027669
6 · The paper itself

Abstract

Inorganic polyphosphates (polyPs) are energy-storing biopolymers synthesized by all three domains of life. PolyP accumulation has been well studied with respect to its role in stress response, but its role in dental disease has received less attention. Dental decay can be promoted by changes in pH as well as the chemical activity of ions such as phosphate in oral fluids at the enamel interface. Previous work has shown that the drawdown of phosphate from biofilm fluids can alter the saturation state of oral fluids to thermodynamically favour mineral dissolution. The members of the Lactobacillaceae are known to accumulate polyP and play a role in early-stage and late-stage dental caries. In this study, we examined the effects of potential metabolic inhibitors on polyP accumulation in

Indexed as

Dental CariesFluoridesPolyphosphatesBiofilmsHumansLactic AcidLacticaseibacillusLacticaseibacillus rhamnosusFluoridesLactic AcidPolyphosphatescariesfluoridegalleinPEP-PTSpolyphosphate

Identifiers

PMID39607745
PMCPMC11604172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.