Evidence map›Paper›PMID 39607696›Full record

Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2026

Appeal and Sensory Characteristics of Oral Nicotine Products in Young Adults Who Vape E-Cigarettes.

Natalia Peraza, Dae Hee Han, Reid C Whaley, Erin A Vogel, John R Monterosso, Maria J Gonzalez Anaya, Devaki J Patel, Nikki S Jafarzadeh, Kurt Hong, Tyler B Mason and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Natalia PerazaInstitute for Addiction Science, University of Southern California, Los Angeles, CA, USA.
Dae Hee HanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Reid C WhaleyDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Erin A VogelHealth Promotion Research Center, University of Oklahoma Health Sciences Center, Oklahoma, OK, USA.ORCID 0000-0002-7193-8720
John R MonterossoInstitute for Addiction Science, University of Southern California, Los Angeles, CA, USA.
Maria J Gonzalez AnayaInstitute for Addiction Science, University of Southern California, Los Angeles, CA, USA.
Devaki J PatelDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Nikki S JafarzadehDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kurt HongDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Tyler B MasonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alayna P TackettCenter for Tobacco Research at The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.ORCID 0000-0003-3818-141X
Adam M LeventhalDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-1217-525X

Funding

USC Tobacco Center of Regulatory ScienceU54CA180905 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI John R Monterosso · 2018 to 2026
$39.0M
Vaping Nicotine and Cannabis Across Adolescence and Young AdulthoodR01CA229617 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BARRINGTON-TRIMIS, JESSICA LOUISE, LEVENTHAL, ADAM MATTHEW · 2019 to 2024
$4.3M
Tobacco Use Treatment Research for Vulnerable PopulationsK24DA048160 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam Matthew Leventhal · 2019 to 2026
$1.4M
Respiratory effects of E-Cigarette use among Youth: A prospective, longitudinal investigationK01HL148907 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TACKETT, ALAYNA PAULINE · 2019 to 2023
$981k
Identifying and Addressing the Effects of Social Media Use on Young Adults' E-Cigarette Use: A Solutions-Oriented ApproachK01DA055073 · NIDA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Erin Alyssa Vogel · 2023 to 2026
$764k
National Cancer Institute and the FDA Center for Tobacco Products (CTP) R01CA229617National Cancer Institute and the FDA Center for Tobacco Products (CTP) U54CA180905National Institute on Drug Abuse under award K01DA055073National Institute on Drug Abuse under award K24DA048160NCI NIH HHS R01 CA229617NCI NIH HHS U54 CA180905NHLBI NIH HHS K01 HL148907NHLBI NIH HHS K01HL148907NIDA NIH HHS K01 DA055073NIDA NIH HHS K24 DA048160
6 · The paper itself

Abstract

introductionThis study applied a novel tobacco regulatory science paradigm to characterize inter-product variation in the appeal and sensory features of emerging commercial and therapeutic oral nicotine products (ONPs) among young adults who vape e-cigarettes. AIMS AND

methodsTwenty-three young adults without ONP experience who use e-cigarettes completed a single-blind, single-visit remote lab study. Participants rated appeal and sensory characteristics during 5-minute standardized self-administrations of eight ONPs (four fruits and four mints) from various brands (Lucy, Rouge, Solace, Nicorette, On!, and Velo). Participants were randomized between-subjects to ONP type (pouches or gum).

resultsGum ONPs were rated sweeter (B = 19.5, 95% Confidence Interval (CI) = 4.3, 34.7), stronger in flavor (B = 25.6, 95% CI = 12.2, 39.0), and lower in tingling sensation (B = -14.0, 95% CI = -27.8, -0.2) than pouches. Fruit-flavored ONPs were sweeter (B = 12.9, 95% CI = 6.1, 19.7) and caused less burning (B = -12.0, 95% CI = -19.5, -4.5) than mint. Product type × flavor interactions found that gum versus pouch enhanced sweetness and flavor strength more for fruit than mint, while pouch versus gum increased burning and harshness more for mint. Nicorette White Ice was most appealing, while Rogue Fruit and Nicorette Mint were less so. Appeal correlated with most types of sensory experiences (rs = -0.33-0.54), except for tingling and burning.

conclusionsNicotine gums may offer a more pleasant sensory experience than pouches for young adults who use e-cigarettes, with variation across brand/flavor variants. IMPLICATIONS: Results indicate that gum ONPs and fruit flavors may offer greater appeal and a more pleasant sensory experience than pouch ONPs and mint flavors for young adults who use e-cigarettes and are ONP-naïve, with heterogeneity in user experience across some brand/flavor variants. This study also introduces a method for assessing the appeal and sensory features of ONPs, which can inform regulatory efforts and strategies to reduce nicotine dependence among young adults who use e-cigarettes.

Indexed as

Electronic Nicotine Delivery SystemsNicotineVapingAdolescentAdultFemaleFlavoring AgentsHumansMaleSingle-Blind MethodTasteYoung AdultFlavoring AgentsNicotine

Identifiers

PMID39607696
PMCPMC12824951

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.