Evidence map›Paper›PMID 39607605›Full record

ArticleSleep & breathing = Schlaf & Atmung2024

Noise-sensitivity during sleep in non-sedated mechanically ventilated patients is associated with weaning duration: a polysomnographic study.

Christophe C S Rault, Jean-Pierre Frat, Quentin Heraud, Stéphanie Ragot, Rémi Coudroy, Marie-Anne Melone, Arnaud W Thille, Xavier Drouot

Abstract read
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In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christophe C S RaultINSERM, Clinical Investigation Center 1402, Research team Is-Alive, University of Poitiers, Faculty of Medicine and Pharmacy, Poitiers, France. Christophe.rault@univ-poitiers.fr.ORCID 0000-0002-0949-2991
Jean-Pierre FratINSERM, Clinical Investigation Center 1402, Research team Is-Alive, University of Poitiers, Faculty of Medicine and Pharmacy, Poitiers, France.
Quentin HeraudINSERM, Clinical Investigation Center 1402, Research team Is-Alive, University of Poitiers, Faculty of Medicine and Pharmacy, Poitiers, France.
Stéphanie RagotINSERM, Clinical Investigation Center 1402, University of Poitiers, Faculty of Medicine and Pharmacy, Poitiers, France.
Rémi CoudroyINSERM, Clinical Investigation Center 1402, Research team Is-Alive, University of Poitiers, Faculty of Medicine and Pharmacy, Poitiers, France.
Marie-Anne MeloneCETAPSUR 3832, University Rouen Normandie, Normandy, France.
Arnaud W ThilleINSERM, Clinical Investigation Center 1402, Research team Is-Alive, University of Poitiers, Faculty of Medicine and Pharmacy, Poitiers, France.
Xavier DrouotINSERM, Clinical Investigation Center 1402, Research team Is-Alive, University of Poitiers, Faculty of Medicine and Pharmacy, Poitiers, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoor sleep is a major concern in intensive care units (ICUs), particularly in mechanically ventilated patients, because it is associated with longer duration of the weaning phase and higher mortality. High noise levels in ICUs are frequently reported by patients as one of the most disturbing sleep-disrupting factors but would be responsible for less than 20% of arousals. This suggests major inter-individual variability in noise sensitivity. Our objectives were to define and assess noise sensitivity in mechanically ventilated patients and to explore its association with sleep duration, sleep quality and weaning duration.

methodsWe retrospectively re-analyzed polysomnographies (PSGs) recorded in 29 non-sedated patients, mechanically ventilated for at least 24 h and difficult to wean (i.e. ≥ 1 spontaneous breathing trial failure). All the arousals were identified on all the PSGs. We calculated mean noise level and identified all noise peaks (an abrupt increase of noise intensity of more than 10 decibels (dBA)) preceding each arousal. Each 21-second period preceding each arousal was divided into seven 3-second bins. We built a pre-event time histogram for each PSG by counting the total number of noise peaks in each bin. If the total number of noise peaks in one bin exceeded the average of the seven bins plus 2 SD, we considered that there was a significant relationship between the number of noise peaks in this bin and the arousal. The patient was then considered as noise-sensitive. Presence of atypical sleep, proportion of sleep stages, and weaning duration were assessed.

resultsNineteen out of 29 patients (66%) were noise-sensitive. Duration of weaning from ventilator was significantly longer in noise-insensitive patients (median [interquartile range] 2 [1-2] versus 5 [2-8] days; p < 0.01). Proportion of N1, N2, N3 sleep stages and rapid eye movement sleep were similar in noise-sensitive and noise-insensitive patients. In contrast, the proportion of patients displaying atypical sleep was higher in noise-insensitive patients.

conclusionOur results report for the first time that most ICU patients were noise-sensitive. Lower noise sensitivity was associated with atypical sleep and could reflect lower brain reactivity to environment.

Indexed as

NoisePolysomnographyVentilator WeaningAdultAgedArousalFemaleHumansMaleMiddle AgedRespiration, ArtificialRetrospective StudiesSleep QualityArousalICUMechanically ventilated patientsNoise-sensitivityPolysomnographyWeaning

Identifiers

PMID39607605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.