ArticleNaunyn-Schmiedeberg's archives of pharmacology2025
Quercetin is a potential therapy for post-infarction NETosis formation.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Heart failure in old hypertensive rats is accompanied by the increase of neutrophil extracellular traps and myeloid-derived suppressor cells.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The role of the bidirectional regulatory network between immune cells and stromal cells in cardiac repair and fibrosis following myocardial infarction.Frontiers in immunology · 2026Review
- Neutrophil extracellular traps in atherosclerosis: current evidence and therapeutic potential of plant-derived metabolites.Frontiers in pharmacology · 2026Review
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Authors and funding
9 authors.
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Abstract
The surgical intervention during myocardial infarction (MI) is associated with the risk of reperfusion injury, infiltration of tissues with polymorphonuclear neutrophils, and neutrophil extracellular trap (NET) formation. We hypothesized that inhibition of NETs with the use of quercetin might be a promising cardioprotective strategy. Wistar rats underwent LAD occlusion (MI) for 40 min followed by 90 min of reperfusion. The MI + Q group received a water-soluble form of quercetin (50 mg/kg, "Corvitin," BCPP, Ukraine) into the tail vein 10 min before reperfusion. The post-MI administration of quercetin significantly alleviated cardiac dysfunction. End-systolic pressure, stroke volume, cardiac output, and stroke work were significantly improved in the MI + Q vs. MI group. NET formation (examined by fluorescence microscopy and Hoechst staining) as well as free DNA in blood plasma was reduced in the MI + Q group that might be one of the mechanisms of the cardioprotective effect of quercetin. Postconditioning with quercetin might be used as a therapeutic tool for the alleviation of reperfusion injury and NETosis inhibition in vivo.
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