Evidence map›Paper›PMID 39607546›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Unveiling the anxiolytic and analgesic effects of citronellal in Swiss mice: in vivo and in silico insights into COX and GABAA receptor pathways.

Muhammad Torequl Islam, Md Sakib Al Hasan, Raihan Chowdhury, Emon Mia, Imam Hossen Rakib, Noshin Tasnim Yana, Heba A S El-Nashar, Siddique Akber Ansari, Irfan Aamer Ansari, Md Amirul Islam and 3 more

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Food science & nutrition · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Muhammad Torequl IslamPharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh. dmt.islam@bsmrstu.edu.bd.
Md Sakib Al HasanDepartment of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.
Raihan ChowdhuryDepartment of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.
Emon MiaDepartment of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.
Imam Hossen RakibDepartment of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.
Noshin Tasnim YanaDepartment of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.
Heba A S El-NasharDepartment of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, 11566, Egypt.
Siddique Akber AnsariDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
Irfan Aamer AnsariDepartment of Drug Science and Technology, University of Turin, 10124, Turin, Italy.
Md Amirul IslamPharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh.
Zainab M AlmarhoonDepartment of Chemistry, College of Science, King Saud University, P. O. Box 2455, 11451, Riyadh, Saudi Arabia.
William N SetzerAromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT, 84043, USA.
Javad Sharifi-RadUniversidad Espíritu Santo, Samborondón, Ecuador. javadsharifirad@uees.edu.ec.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to evaluate the analgesic and anxiolytic effects of citronellal (CTL) in Swiss mice using two new sensitive and economic mouse models along with possible molecular mechanisms through in silico studies. For this, we employed marble displacement and spiked-field apparatus to check the anxiolytic and analgesic effects, respectively. In silico studies were done against cyclooxygenase (COX) enzymes and GABA

Indexed as

Acyclic MonoterpenesAnalgesicsAnti-Anxiety AgentsMonoterpenesProstaglandin-Endoperoxide SynthasesReceptors, GABA-AAldehydesAnimalsBehavior, AnimalComputer SimulationDiazepamDiclofenacMaleMiceMolecular Docking SimulationSignal TransductionAcyclic MonoterpenesAldehydesAnalgesicsAnti-Anxiety AgentscitronellalDiazepamDiclofenacMonoterpenesProstaglandin-Endoperoxide SynthasesReceptors, GABA-AAnxietyBioactive compoundMarble displacementPainSpiked-field

Identifiers

PMID39607546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.