Evidence map›Paper›PMID 39607503›Full record

Trial reportEuropean journal of nutrition2024

Association of dietary patterns derived by reduced-rank regression with colorectal cancer risk and mortality.

Zegeye Abebe, Molla Mesele Wassie, Phuc D Nguyen, Amy C Reynolds, Yohannes Adama Melaku

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zegeye AbebeFlinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, 5042, Australia. abeb0011@flinders.edu.au.ORCID http://orcid.org/0000-0001-6922-0376
Molla Mesele WassieFlinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, 5042, Australia.
Phuc D NguyenFlinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, 5042, Australia.
Amy C ReynoldsFlinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, 5042, Australia.
Yohannes Adama MelakuFlinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, 5042, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUnhealthy dietary patterns contribute to an increased risk of colorectal cancer (CRC). Limited prior research has used reduced rank regression (RRR) to assess dietary patterns relative to CRC risk. This study aimed to identify dietary patterns derived by RRR and assess their associations with CRC risk and mortality.

methodsWe used data from the multicentre Prostate, Lung, Colorectal, and Ovarian Cancer Screening (PLCO) trial. Dietary intake was assessed using a Dietary History Questionnaire. In the RRR intake of fibre, folate, and the percentage of energy from carbohydrates, saturated and unsaturated fatty acids were used as response variables. Cox models and competing risk survival regression, with age as the time scale, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for CRC risk and mortality, respectively.

resultsThe median follow-up time for CRC risk (n = 1044) and mortality (n = 499) was 9.4 years (Interquartile Range: 8. 0, 10.1) and 16.9 years (11.9, 18.6), respectively. Two dietary patterns were identified: the first was characterised by high carbohydrate, folate and low fatty acid intake, and the second by high fibre and unsaturated fatty acid. Compared to participants in the first tertile of the high fibre and unsaturated fatty acid pattern, those in the third tertile had a lower risk of CRC (HR = 0.88; 95% CI: 0.76, 1.03), and colon cancer (HR = 0.85; 95% CI: 0.72, 1.01). Conversely, the high carbohydrate, high folate and low fatty acid pattern had no association with CRC outcomes. None of the dietary patterns showed associations with rectal cancer or CRC mortality.

conclusionA diet enriched with high fibre and unsaturated fatty acids may reduce the risk of CRC. These results highlight the potential protective effect of adequate fibre intake in conjunction with high consumption of unsaturated fatty acids against CRC.

Indexed as

Colorectal NeoplasmsDietAgedDietary FiberFeeding BehaviorFemaleFolic AcidFollow-Up StudiesHumansMaleMiddle AgedProportional Hazards ModelsRegression AnalysisRisk FactorsSurveys and QuestionnairesDietary FiberFolic AcidColorectal cancerHealthy dietHybrid dietary data analysisLongitudinal dataReduced rank regressionSurvival analysis

Identifiers

PMID39607503

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.