Evidence map›Paper›PMID 39607498›Full record

ArticleJournal of gastroenterology2025

Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study.

Makoto Okabe, Shuji Yamamoto, Masahiro Shiokawa, Tadakazu Hisamatsu, Hajime Yamazaki, Risa Nakanishi, Kensuke Hamada, Hiroki Kitamoto, Takeshi Kuwada, Norimitsu Uza and 32 more

Erratum issuedAbstract readMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Review
  9. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

42 authors.

Makoto OkabeDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Shuji Yamamoto *Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. shuyama@kuhp.kyoto-u.ac.jp.
Masahiro Shiokawa *Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. machan@kuhp.kyoto-u.ac.jp.
Tadakazu Hisamatsu *Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka-shi, Tokyo, 181-8611, Japan. thisamatsu@ks.kyorin-u.ac.jp.
Hajime YamazakiSection of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Risa NakanishiDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Kensuke HamadaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Hiroki KitamotoDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Takeshi KuwadaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Norimitsu UzaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Aki SakataniDivision of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, 078-8510, Japan.
Toshimitsu FujiiDepartment of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan.
Masashi OhnoDepartment of Medicine, Shiga University of Medical Science, Otsu, 520-2192, Japan.
Minoru MatsuuraDepartment of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka-shi, Tokyo, 181-8611, Japan.
Tomoyoshi ShibuyaDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, 113-8421, Japan.
Naoki OhmiyaDepartment of Advanced Endoscopy, Fujita Health University School of Medicine, Toyoake, 470-1192, Japan.
Makoto OoiDivision of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, 650-0017, Japan.
Namiko HoshiDivision of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, 650-0017, Japan.
Kei MoriyaDepartment of Gastroenterology, Nara Prefecture General Medical Center, Nara, 630-8581, Japan.
Kiichiro TsuchiyaDepartment of Gastroenterology, Institute of Medicine, University of Tsukuba, Tsukuba, 305-8576, Japan.
Yoshiharu YamaguchiDivision of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.
Reiko KunisakiInflammatory Bowel Disease Center, Yokohama City University Medical Center, Yokohama, 232-0024, Japan.
Masahiro TakaharaDepartment of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, 700-8558, Japan.
Tomohisa TakagiDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Tetsuo TakeharaDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
Fumihito HiraiDepartment of Gastroenterology, Faculty of Medicine, Fukuoka University, Fukuoka, 814-0180, Japan.
Kazuki KakimotoSecond Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, 569-8686, Japan.
Motohiro EsakiDivision of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, 849-8501, Japan.
Hiroshi NakaseDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, 060-8543, Japan.
Fukunori KinjoCenter for Gastroenterology, Urasoe General Hospital, Urasoe, 901-2102, Japan.
Takehiro TorisuDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Shuji KanmuraDivision of Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890-8520, Japan.
Kazuyuki NarimatsuDepartment of Internal Medicine, National Defence Medical College, Tokorozawa, 359-8513, Japan.
Katsuyoshi MatsuokaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Sakura Medical Center, Sakura, 285-8741, Japan.
Hiroto HiragaDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8563, Japan.
Kaoru YokoyamaDepartment of Gastroenterology, Kitasato University School of Medicine, Kanagawa, 252-0375, Japan.
Yusuke HonzawaDivision of Gastroenterology and Hepatology, Third Department of Internal Medicine, Kansai Medical University, Osaka, 573-1010, Japan.
Makoto NaganumaDivision of Gastroenterology and Hepatology, Third Department of Internal Medicine, Kansai Medical University, Osaka, 573-1010, Japan.
Masayuki SarutaDivision of Internal Medicine, Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, 105-8471, Japan.
Yuzo KodamaDivision of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, 650-0017, Japan.
Tsutomu ChibaDepartment of Gastroenterology and Hepatology, Kansai Electric Power Hospital, Fukushima-ku, Osaka, 553-0003, Japan.
Hiroshi SenoDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Funding

Agency for Medical Research and Development 22ek0109566
6 · The paper itself

Abstract

backgroundA serum biomarker for diagnosing ulcerative colitis (UC) remains to be established. Although we recently reported an anti-integrin αvβ6 antibody (V6 Ab) for diagnosing UC with high sensitivity and specificity, no large-scale validation study exists. This study aimed to validate the diagnostic value of V6 Ab for UC using a nationwide multicenter cohort study.

methodsWe measured V6 Ab titers in patients definitively diagnosed with UC, Crohn's disease (CD), or other gastrointestinal disorders (OGDs). The primary outcome was the diagnostic value of V6 Ab. Secondary outcomes were factors associated with false-negative results in patients with UC and false-positive results in patients without UC and the heterogeneity of the diagnostic value of V6 Ab among the participating facilities.

resultsWe enrolled 1241, 796, and 206 patients with UC, CD, and OGD, respectively, from 28 Japanese high-volume referral centers. The diagnostic sensitivity of V6 Ab for UC was 87.7%, and its specificities for CD and OGDs were 82.0% and 87.4%, respectively. Multivariable logistic regression analysis showed that false-negative results were associated with older age at the time of sample collection, current smokers, lower partial Mayo score, and not receiving advanced therapies in patients with UC, and false-positive results were associated with colonic CD in patients with CD. No factor was associated with false-positive results in patients with OGDs. There were no significant differences in the diagnostic value of V6 Ab among the centers.

conclusionsThe diagnostic value of V6 Ab for UC was validated in the large-scale nationwide multicenter study.

Indexed as

Antigens, NeoplasmBiomarkersColitis, UlcerativeIntegrinsSensitivity and SpecificityAdultAgedCohort StudiesCrohn DiseaseFalse Negative ReactionsFalse Positive ReactionsFemaleHumansJapanMaleMiddle AgedAntigens, NeoplasmBiomarkersintegrin alphavbeta6IntegrinsAnti-integrin αvβ6 antibodyColonic Crohn’s diseaseDiagnostic biomarkerUlcerative colitis

Identifiers

PMID39607498
PMCPMC11717824

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