Evidence map›Paper›PMID 39607494›Full record

ArticleTissue engineering. Part A2025

Evaluation of Dexamethasone-Eluting Cell-Seeded Constructs in a Preclinical Canine Model of Cartilage Repair.

Andy J Lee, Lianna R Gangi, Yizhong Jenny Hu, Andreea T Dinescu, X Edward Guo, Chantelle C Bozynski, Keiichi Kuroki, Aaron M Stoker, Kacey G Marra, Gerard A Ateshian and 2 more

Abstract read
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In one paragraph

Article in Tissue engineering. Part A, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andy J LeeDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
Lianna R GangiDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
Yizhong Jenny HuDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
Andreea T DinescuDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
X Edward GuoDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
Chantelle C BozynskiThompson Laboratory for Regenerative Orthopaedics, Missouri Orthopaedic Institute, Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri, USA.
Keiichi KurokiThompson Laboratory for Regenerative Orthopaedics, Missouri Orthopaedic Institute, Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri, USA.
Aaron M StokerThompson Laboratory for Regenerative Orthopaedics, Missouri Orthopaedic Institute, Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri, USA.
Kacey G MarraDepartment of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Gerard A AteshianDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
James L CookThompson Laboratory for Regenerative Orthopaedics, Missouri Orthopaedic Institute, Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri, USA.
Clark T HungDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.

Funding

Tissue Engineering Resource Center: TTDP41EB027062 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gordana Vunjak-Novakovic · 2019 to 2026
$12.6M
Incorporation of Dexamethasone Delivery within Engineered CartilageR01AR068133 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HUNG, CLARK T. · 2016 to 2021
$2.8M
NIAMS NIH HHS R01 AR068133NIBIB NIH HHS P41 EB027062
6 · The paper itself

Abstract

In this 12-month long, preclinical large animal study using a canine model, we report that engineered osteochondral grafts (comprised of allogeneic chondrocyte-seeded hydrogels with the capacity for sustained release of the corticosteroid dexamethasone [DEX], cultured to functional mechanical properties, and incorporated over porous titanium bases), can successfully repair damaged cartilage. DEX release from within engineered cartilage was hypothesized to improve initial cartilage repair by modulating the local inflammatory environment, which was also associated with suppressed degenerative changes exhibited by menisci and synovium. We note that not all histological and clinical outcomes at an intermediary time point of three months paralleled 12-month outcomes, which emphasizes the importance of

Indexed as

Cartilage, ArticularChondrocytesDexamethasoneTissue EngineeringTissue ScaffoldsWound HealingAnimalsDogsDexamethasonecartilagedexamethasoneosteochondral allograftpreclinicaltissue engineering

Identifiers

PMID39607494
PMCPMC11971544

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.