Evidence map›Paper›PMID 39607361›Full record

ArticleEpilepsia2025

Basic and preclinical epilepsy research Scientists' perception of clinical epileptology.

Marco de Curtis, Melody Asukile, Giulia Battaglia, Annabelle Sellin, Esper Cavalheiro, Marian Galovic, Jennifer N Gelinas, Akio Ikeda, Manisha Patel, Piero Perucca and 10 more

Abstract read
In one paragraph

Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Marco de CurtisEpilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID 0000-0001-7443-6737
Melody AsukileSchool of Medicine, University of Zambia, Lusaka, Zambia.ORCID 0000-0003-3745-8982
Giulia BattagliaEpilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID 0000-0001-7496-2083
Annabelle SellinInternational League Against Epilepsy.
Esper CavalheiroDepartamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo/Escola Paulista de Medicina, Brazil.
Marian GalovicDepartment of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Jennifer N GelinasDepartment of Neurology, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-1164-638X
Akio IkedaEpilepsy Department, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Manisha PatelPharmaceutical Sciences Department, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Anschutz, Colorado, USA.
Piero PeruccaDepartment of Medicine (Austin Health), Department of Neurology, The University of Melbourne, and Bladin-Berkovic Comprehensive Epilepsy Program, Heidelberg, Victoria, Australia.ORCID 0000-0002-7855-7066
Heidrun PotschkaInstitute of Pharmacology, Toxicology and Pharmacy, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0003-1506-0252
Luisa RochaPharmacobiology Department. Center for Research and Advanced Studies, Mexico City, Mexico.ORCID 0000-0003-4495-9427
Chahnez TrikiChild Neurology Department, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia.ORCID 0000-0003-2918-3819
Jo M WilmshurstPaediatric Neurology Department, Red Cross War Memorial Children's Hospital, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-7328-1796
William GaillardDivision of Epilepsy and Neurophysiology, Department of Pediatric Neurology, Children's National Hospital, Washington, DC, USA.ORCID 0000-0001-5709-0033
Francesco DeleoEpilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID 0000-0003-0808-3042
Fernando CendesDepartment of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
J Helen CrossNeuroscience Unit, University College London NIHR BRC Great Ormond Street Institute of Child Health, University College, London, UK.ORCID 0000-0001-7345-4829
Aristea S GalanopoulouSaul R. Korey Department of Neurology, Dominick P. Purpura Department of Neuroscience, Isabelle Rapin Division of Child Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-0472-2903
Research & Innovation Task Force of the ILAE

Funding

Translational Platform for Epilepsy Therapy and Biomarker DiscoveryR01NS127524 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Denes V. Agoston, LISA D COLES · 2022 to 2026
$11.0M
NUCLEUS ACCUMBENS PROCESSING OF REWARD-PREDICTIVE CUESR01DA019473 · NIDA · ERNEST GALLO CLINIC AND RESEARCH CENTER · PI SALEEM M NICOLA · 2006 to 2026
$8.1M
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Defining the mechanism of coma in cerebral malariaR01AI164864 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Johanna Patricia Daily · 2022 to 2026
$2.7M
NIAID NIH HHS R01 AI164864NICHD NIH HHS P50 HD105352NIDA NIH HHS R01 DA019473NINDS NIH HHS R01 NS127524
6 · The paper itself

Abstract

The interaction between basic science epilepsy researchers and clinical epileptologists is a longstanding issue. Efforts to provide opportunities for a dialogue between preclinical and clinical epilepsy professionals are crucial to reduce the knowledge gap between them and improve the translational success of neurobiology-based research. The International League Against Epilepsy (ILAE) Research and Innovation Task Force circulated a survey to investigate the need for an update on new clinical epilepsy concepts within the basic science community. The 336 respondents included basic scientists (BS), preclinical scientists (PCSs), and/or clinical scientists (CSs). The majority of the 237 BSs/PCSs were engaged in preclinical studies in translational epilepsy research and declared translational research as a priority research interest. Fewer respondents from low-middle-income countries than from upper-middle or high-income countries (40.7% vs 65%) considered translational research a critical aspect of their research. A broad understanding of both clinical and neurobiological aspects of epilepsy was declared by 48% of BSs/PCSs; 96% of CSs declared a superficial knowledge of neurobiology of epilepsy. Most BSs/PCSs were aware that epilepsy is a complex condition that should be investigated with the help of clinical epileptologists, even though concerns were expressed on the relationship with clinicians. A focused training program on emerging clinical epileptological aspects tailored for BSs/PCSs was recommended by 81% of the participants; the majority of respondents preferred either 1- or 2-week in-presence tutoring or continuous online training coordinated by ILAE at the regional/national level. The survey also underscored the value of educational programs on neurobiology of epilepsy targeting CSs and low-middle-income countries (LMIC) investigators.

Indexed as

Biomedical ResearchEpilepsyResearch PersonnelHumansSurveys and QuestionnairesTranslational Research, Biomedicalbasic scienceeducationepilepsypreclinicaltraining

Identifiers

PMID39607361
PMCPMC11742547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.