Evidence map›Paper›PMID 39607092›Full record

ArticleBrain and behavior2024

Patients' Characteristics Associated With Size of Ruptured and Unruptured Intracranial Aneurysms.

Thiemo Florin Dinger, Mehdi Chihi, Meltem Gümüs, Christoph Rieß, Alejandro Nicolas Santos, Mats Leif Moskopp, Jan Rodemerk, Maximilian Schüßler, Marvin Darkwah Oppong, Yan Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Thiemo Florin DingerDepartment of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C-TNBS), University Hospital of Essen, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.ORCID 0000-0002-7009-9099
Mehdi ChihiDepartment of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C-TNBS), University Hospital of Essen, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.
Meltem GümüsDepartment of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C-TNBS), University Hospital of Essen, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.
Christoph RießDepartment of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C-TNBS), University Hospital of Essen, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.
Alejandro Nicolas SantosDepartment of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C-TNBS), University Hospital of Essen, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.ORCID 0000-0002-6616-5313
Mats Leif MoskoppDepartment of Neurosurgery, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Jan RodemerkDepartment of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C-TNBS), University Hospital of Essen, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.
Maximilian SchüßlerUniversity Hospital Essen, Institute for Diagnostic and Interventional Radiology and Neuroradiology, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.
Marvin Darkwah OppongDepartment of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C-TNBS), University Hospital of Essen, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.ORCID 0000-0003-1021-5024
Yan LiUniversity Hospital Essen, Institute for Diagnostic and Interventional Radiology and Neuroradiology, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.
Karsten Henning WredeDepartment of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C-TNBS), University Hospital of Essen, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.ORCID 0000-0001-7076-3503
Philipp René DammannDepartment of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C-TNBS), University Hospital of Essen, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.
Ulrich SureDepartment of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C-TNBS), University Hospital of Essen, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.
Ramazan JabbarliDepartment of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C-TNBS), University Hospital of Essen, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.

Funding

Open Access Publication Fund of the University of Duisburg-Essen
6 · The paper itself

Abstract

objectiveThe size of unruptured intracranial aneurysms (UIA) remains the most crucial risk factor for treatment decisions. On the other side, there is a non-negligible portion of small ruptured IA and large stable UIA. This study aimed to identify the patients' characteristics related to IA size in the context of IA rupture status.

methodsA total of 2152 patients, with 1002 being hospitalized for an acute aneurysmal subarachnoid hemorrhage (SAH), were included from our institutional IA database. Different demographic and clinical characteristics of patients and IA were collected. IA size was the study endpoint, assessed as continuous variable in univariate and multivariable linear regression analysis, separately for ruptured (R) IA and UIA.

resultsThe mean IA size was 8.3 and 7.3 mm in the UIA and RIA subpopulations, respectively. Higher age (p = 0.003) and baseline blood urea level (p < 0.001) were independently associated with increasing UIA size. In contrast, location at the posterior circulation (p < 0.001), familiar intracranial aneurysms (p < 0.001), serum potassium (p = 0.006), and total serum protein (p = 0.019) were related to smaller UIA size in the multivariate analysis. For RIA, a statistically significant and independent association was detected for location (p = 0.019), history of gastrointestinal diseases (p = 0.042), and levothyroxine intake (p = 0.002).

conclusionsIdentification of clinical characteristics related to the size of ruptured and unruptured IA allows a more differentiated view on the genesis of RIA and UIA and the value of sack size as a basis for therapeutic decision-making. More research is needed to verify the identified risk factors.

Indexed as

Aneurysm, RupturedIntracranial AneurysmAdultAgedAge FactorsFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsSubarachnoid Hemorrhagedestabilizing factorsintracranial aneurysmssize

Identifiers

PMID39607092
PMCPMC11603431

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.