ArticleBrain and behavior2024
Causal Effects of Sleep Quality on Primary Headache and the Mediation via Gut Microbiota: A Mendelian Randomization Study.
Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Intermittent fasting alleviates hyperalgesia in ovariectomized mice via gut microbiota remodeling.NPJ biofilms and microbiomes · 2026Article
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Abstract
backgroundPrevious studies have shown that sleep quality plays an essential role in primary headaches to varying degrees. However, it is unclear precisely whether gut microbiota plays a critical role in mediating changes in sleep quality and affecting primary headaches.
methodsWe utilized Mendelian randomization (MR) to examine the causal relationships between sleep quality and primary headaches. The data encompass eight sleep traits (staying asleep during periods of anxiety, trouble falling asleep, daytime dozing, sleep apnea syndrome, oversleeping, undersleeping, snoring, and sleeplessness). The primary statistical method employed was inverse variance weighting. Eventually, we explored whether gut microbiota mediate the relationship between sleep quality and primary headaches.
resultsOur study found that a genetic predisposition to poor sleep quality increases the risk of primary headaches. Two-step MR analysis revealed that the genus Coprococcus1 mediates the causal relationship between trouble falling asleep and cluster headaches, with a mediating effect of 23.6%. These findings could inform targeted interventions and treatments for primary headaches.
conclusionThis study suggests that trouble falling asleep increases the incidence of cluster headaches mediated by gut microbiota. It highlights the crucial impact of sleep quality on primary headaches.
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