ArticlePostepy dermatologii i alergologii2024
Analysis of the correlation between the levels of HIF-1α and miR-199a in lesions and the psoriasis severity index.
Article in Postepy dermatologii i alergologii, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Trained Immunity and Its Potential Implications in the Etiopathogenesis of Hidradenitis Suppurativa: A New Paradigm in Chronic Inflammation?Experimental dermatology · 2025Review
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4 authors.
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Abstract
Introduction: The pathogenesis of psoriasis is complex. Previous bioinformatics studies have found differential expression of HIF-1α and miR-199 in psoriasis, but the correlation between miR-199a and HIF-1α and the severity of psoriasis is still unclear. This study found differential expression of HIF-1α and miR-199a levels in the skin lesions of patients with different degrees of psoriasis. HIF-1α mRNA and miR-199a are PASI influencing factors, and the levels of HIF-1 α and miR-199a in the skin lesions can serve as potential indicators for evaluating the severity index of psoriasis. Aim: To examine the relationships between the levels of HIF-1α and miR-199a and psoriasis severity. Material and methods: Sixty-five patients with psoriasis vulgaris treated from January 2023 to May 2024 were divided into a mild group ( Results: The level of miR-199a in lesions in the observation group (group B) was lower than that in group A, but the level of HIF-1αmRNA in group B was greater than that in group A. The level of miR-199a in moderate and severe psoriasis patients was lower than that in mild psoriasis patients, and that in severe psoriasis patients was lower than that in moderate psoriasis patients. HIF-1α mRNA in lesions was positively associated with the PASI in psoriasis patients, and the miR-199a level in lesions was positively associated with the PASI in psoriasis patients. Furthermore, taking the PASI as the dependent variable and HIF-1αmRNA and miR-199a with a linear relationship with the dependent variable as the independent variables, multiple stepwise regression analysis showed that HIF-1α mRNA and miR-199a influenced the PASI. Conclusions: HIF-1α and miR-199a are differentially expressed in the lesions of patients with different severities of psoriasis. The HIF-1α and miR-199a levels in lesions can be used as potential indices to evaluate the severity of psoriasis.
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