ArticleCureus2024
Adult-Onset Hemophagocytic Lymphohistiocytosis Associated With Epstein-Barr Virus, Lyme Disease, and Anaplasmosis.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Adult-onset hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterized by dysregulated immune activation. Diagnosing HLH poses significant challenges due to its nonspecific clinical presentation, which often mimics infections, malignancies, and autoimmune diseases. Early recognition and prompt initiation of immunosuppressive therapy are crucial, as delayed treatment is associated with a high risk of mortality. We present a unique case of HLH triggered by a combination of Epstein-Barr virus (EBV), Lyme disease, and anaplasmosis, underscoring the complexity of diagnosing and managing this condition. The patient initially presented with fever, hypotension, and altered mental status, raising concerns for septic shock. However, a comprehensive diagnostic workup, including infectious disease testing, hematologic evaluation, and bone marrow biopsy, revealed HLH with evidence of EBV viremia,
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