ArticleCureus2024
Study of HOXB13 Gene Variants in Prostate Cancer Patients.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Imbalance in WNT: retinoic acid signaling dysregulates HOX gene expression: implications for cancer stem cell heterogeneity and CRC patient survival.Stem cells translational medicine · 2026Article
- Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review).International journal of oncology · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProstate cancer (PC) is a prevalent malignancy with a significant hereditary component. The HOXB13 gene, encoding a transcription factor involved in prostate development, has been implicated in PC risk.
objectiveThe objective of this study was to assess the existence of HOXB13 mutations in PC patients.
methodThe retrospective study included 33 PC patients and 23 controls. Demographic data, family history, and smoking habits were recorded. Prostate-specific antigen (PSA) levels were measured. We investigated the second exon of HOXB13 after extracting genomic DNA from blood samples for mutations using polymerase chain reaction and Sanger sequencing.
resultPC patients had a higher mean age (64.7 years), more frequent positive family history (63.64%, N = 21), and higher smoking prevalence (60.61%, N = 20) compared to controls. PSA levels were significantly elevated in patients (76.58 ng/ml) versus controls (7.22 ng/ml). HOXB13 mutations, including thymine (3.03%, N = 1), guanine (27.27%, N = 9), and adenine (33.33%, N = 11) mutations, were observed in patients, while no mutations were found in controls.
conclusionPC patients had higher mean age, more positive family histories, higher smoking rates, and elevated PSA levels. HOXB13 mutations were significantly higher in patients compared to controls. These findings emphasize the roles of HOXB13, age, family history, smoking, and PSA in PC risk stratification.
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