ArticleResearch square2024
Nitrous Oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect.
Joseph Cichon, Thomas T Joseph, Xinguo Lu, Andrzej Z Wasilczuk, Max B Kelz, Steven J Mennerick, Charles F Zorumski, Peter Nagele
Abstract readPreprint
In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Xinguo LuDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Max B KelzDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Steven J MennerickDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Charles F ZorumskiDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Peter NageleDepartment of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois.
Funding
Neuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI MAGUIRE, JAMIE LYNN · 2021 to 2025
$12.2MNEURONAL BASIS UNDERLYING VOLATILE ANESTHETIC INDUCED HYPNOSISR01GM088156 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KELZ, MAX · 2010 to 2021
$3.8MGABAA RECEPTOR POPULATIONS IN HIPPOCAMPUS AND THALAMUSR01MH123748 · NIMH · WASHINGTON UNIVERSITY · PI MENNERICK, STEVEN J · 2021 to 2025
$2.4MBrain Wide Anesthetic-Active Neuronal NetworkR01GM151556 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Alexander Proekt · 2023 to 2026
$2.2MCellular and circuit mechanisms of the therapeutic action of inhaled nitrous oxide in rodent models of chronic stressR35GM151160 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI JOSEPH CICHON · 2023 to 2026
$1.7MEfficient prediction of transmembrane binding sites for anesthetic ligandsK08GM139031 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI JOSEPH, THOMAS THENGANPALLIL · 2020 to 2024
$984kNIGMS NIH HHS K08 GM139031NIGMS NIH HHS R01 GM088156NIGMS NIH HHS R01 GM151556NIGMS NIH HHS R35 GM151160NIMH NIH HHS P50 MH122379NIMH NIH HHS R01 MH123748
6 · The paper itselfAbstract
Identifiers
PMID39606485
PMCPMC11601843
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