Evidence map›Paper›PMID 39606469›Full record

ArticleResearch square2024

Evolutionary loss of an antibiotic efflux pump increases

Sheryl E Fernandes, Humberto Ortega, Mylene Vaillancourt, Anna Clara M Galdino, Aleksandr Stotland, Kyu Shik Mun, Diane Aguilar, Yohei Doi, Janet S Lee, Elizabeth B Burgener and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Sheryl E FernandesDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-3347-6107
Humberto OrtegaBinghamton Biofilm Research Center, Department of Biological Sciences, Binghamton University, Binghamton, NY, USA.
Mylene VaillancourtDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Anna Clara M GaldinoDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Aleksandr StotlandSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Kyu Shik MunBoard of Governor's Regenerative Medicine Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Diane AguilarDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Yohei DoiCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Janet S LeeDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID https://orcid.org/0000-0002-6812-6043
Elizabeth B BurgenerDepartment of Pediatrics, Division of Pulmonology, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-8969-6232
Jeffrey E BarrickDepartment of Molecular Biosciences, Center for Systems and Synthetic Biology, The University of Texas at Austin, Austin, TX, USA.ORCID https://orcid.org/0000-0003-0888-7358
Jeffrey W SchertzerBinghamton Biofilm Research Center, Department of Biological Sciences, Binghamton University, Binghamton, NY, USA.ORCID https://orcid.org/0000-0002-7658-0860
Peter JorthDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-0981-740X

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMIT GAGGAR · 2007 to 2026
$23.0M
Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3M
Mechanisms of host protection against pathogen-secreted proteases in acute lung injuryR01HL136143 · NHLBI · WASHINGTON UNIVERSITY · PI LEE, JANET SOJUNG · 2017 to 2024
$4.4M
The role of ACOD1 in immunomodulation in intrapulmonary Klebsiella pneumoniae infectionR01HL142084 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, KONG · 2018 to 2021
$2.4M
Molecular mechanisms of hypervirulence in antibiotic-resistant Pseudomonas aeruginosaR01AI146425 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI JORTH, PETER ALLAN · 2020 to 2023
$2.3M
Patient-Oriented Research in Acute Lung Injury and Host Defense in the ICUK24HL143285 · NHLBI · WASHINGTON UNIVERSITY · PI LEE, JANET SOJUNG · 2019 to 2023
$579k
Determining mechanisms and prevalence of virulence-enhancing resistance mutationsK22AI127473 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI JORTH, PETER ALLAN · 2018 to 2019
$268k
NHLBI NIH HHS K24 HL143285NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R01 HL136143NHLBI NIH HHS R01 HL142084NIAID NIH HHS K22 AI127473NIAID NIH HHS R01 AI146425NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

Antibiotic resistance is one of the most pressing threats to human health, yet recent work highlights how loss of resistance may also drive pathogenesis in some bacteria. In two recent studies, we found that β-lactam antibiotic and nutrient stresses faced during infection selected for the genetic inactivation of the

Identifiers

PMID39606469
PMCPMC11601840

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.