Evidence map›Paper›PMID 39606455›Full record

ArticleResearch square2024

Heterogeneity of IKZF1 genomic alterations and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia.

Charles Mullighan, Ruth Wangondu, Emily Ashcraft, Ti-Cheng Chang, Kathryn Roberts, Samuel Brady, Yiping Fan, William Evans, Mary Relling, Kristine Crews and 17 more

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Charles MullighanSt Jude Children's Research Hospital.ORCID https://orcid.org/0000-0002-1871-1850
Ruth WangonduSt Jude Children's Research Hospital.
Emily AshcraftSt Jude Children's Research Hospital.
Ti-Cheng ChangSt. Jude Children's Research Hospital.
Kathryn RobertsSt. Jude Children's Research Hospital.ORCID https://orcid.org/0000-0001-7626-4043
Samuel BradyUniversity of Utah.ORCID https://orcid.org/0000-0001-5518-7800
Yiping FanDepartment of Computational Biology, St. Jude Children's Research Hospital.
William EvansSt. Jude Children's Research Hospital.ORCID https://orcid.org/0000-0002-9333-5322
Mary RellingSt. Jude Children's Research Hospital.ORCID https://orcid.org/0000-0002-3720-9591
Kristine CrewsSt. Jude Children's Research Hospital.ORCID https://orcid.org/0000-0002-7558-558X
Jun YangSt. Jude Children's Research Hospital.
Wenjian YangSt. Jude Children's Research Hospital.ORCID https://orcid.org/0000-0002-7305-5649
Stanley PoundsSt. Jude Children's Research Hospital.ORCID https://orcid.org/0000-0002-9167-2114
Gang WuSt Jude Children's Research Hospital.ORCID https://orcid.org/0000-0002-1678-5864
Meenakshi DevidasSt. Jude Children's Research Hospital.ORCID https://orcid.org/0000-0002-1099-3478
Kelly MaloneyUniversity of Colorado School of Medicine.
Leonard MattanoHARP Pharma Consulting.ORCID https://orcid.org/0000-0002-8409-0589
Reuven SchoreChildren's National Hopital.ORCID https://orcid.org/0000-0002-1582-2168
Anne AngiolilloServier Pharmaceuticals.
Eric LarsenMaine Children's Cancer Program.
Wanda SalzerWalter Reed National Military Medical Center.
Michael BurkeMedical College of Wisconsin.ORCID https://orcid.org/0000-0001-6626-2773
Mignon LohSeattle Children's Hospital.ORCID https://orcid.org/0000-0003-4099-4700
Sima JehaSt Jude Children's Research Hospital.
Ching-Hon PuiSt Jude Children's Research Hospital.ORCID https://orcid.org/0000-0003-0303-5658
Hiroto InabaSt. Jude Children's Research Hospital.ORCID https://orcid.org/0000-0003-0605-7342
Cheng ChengSt Jude Children's Research Hospital.

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Children's Oncology Group Statistics &Data Center GrantU10CA098413 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DEVIDAS, MEENAKSHI · 2003 to 2013
$67.5M
COG U24 Funding 2026-2027U24CA196173 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Mignon Lee-Cheun Loh, Nilsa Del Carmen Ramirez Milan · 2015 to 2026
$62.5M
Support for Human Specimen Banking in NCI-Supported Cancer Clinical TrialsU24CA114766 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RAMIREZ MILAN, NILSA DEL CARMEN · 2005 to 2014
$14.5M
Translating genomic discoveries to improved outcomes for high risk acute leukemiaR35CA197695 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Charles G Mullighan · 2017 to 2026
$11.4M
NCI NIH HHS HHSN261201500003CNCI NIH HHS HHSN261201500003INCI NIH HHS P30 CA015704NCI NIH HHS P30 CA021765NCI NIH HHS R35 CA197695NCI NIH HHS U10 CA098413NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U24 CA114766NCI NIH HHS U24 CA196173
6 · The paper itself

Abstract

Genomic alterations of

Identifiers

PMID39606455
PMCPMC11601832

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.