Evidence map›Paper›PMID 39606435›Full record

ArticleResearch square2024

An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo.

Hin Chu, Huiping Shuai, Jingxin Qiao, Chaemin Yoon, Guo Zhang, Yuxin Hou, Xiaoyan Xia, Lei Wang, Xinyue Deng, Yifei Wang and 22 more

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Hin ChuThe University of Hong Kong.ORCID https://orcid.org/0000-0003-2855-9837
Huiping ShuaiThe University of Hong Kong.ORCID https://orcid.org/0000-0001-8078-4113
Jingxin QiaoSichuan University.
Chaemin YoonThe University of Hong Kong.
Guo ZhangSichuan University.
Yuxin HouThe University of Hong Kong.
Xiaoyan XiaSichuan University.
Lei WangThe University of Hong Kong.
Xinyue DengSichuan University.
Yifei WangSichuan University.
Qingquan LiNational Institute of Biological Sciences.
Lianzhao DuThe University of Hong Kong.
Yuanchen LiuThe University of Hong Kong.
Minmin ZhouThe University of Hong Kong.
Hoi Ting WongThe University of Hong Kong.
Huan LiuThe University of Hong Kong.
Bingjie HuThe University of Hong Kong.ORCID https://orcid.org/0000-0002-6677-9454
Yan ChenSichuan University.
Zhen FangWest China Hospital, Sichuan University.ORCID https://orcid.org/0000-0003-4310-7898
Ziyi XiaSichuan University.
Yue ChaiThe University of Hong Kong.
Jialu ShiThe University of Hong Kong.
Yang WangThe University of Hong.
Tianrenzheng ZhuThe University of Hong Kong.
Honglei ZhangThe University of Hong Kong.
Shuofeng YuanThe University of Hong Kong.
Jie Zhouthe University of Hong Kong.ORCID https://orcid.org/0000-0002-2948-3873
Jasper ChanThe University of Hong Kong.ORCID https://orcid.org/0000-0001-6336-6657
Kwok-Yung YuenThe University of Hong Kong.ORCID https://orcid.org/0000-0002-2083-1552
Chunfu XuNational Institute of Biological Sciences, Beijing.ORCID https://orcid.org/0000-0002-8668-0566
Shengyong YangSichuan University.ORCID https://orcid.org/0000-0001-5147-3746

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronaviruses have caused three major endemics in the past two decades. Alarmingly, recent identification of novel zoonotic coronaviruses that caused human infections suggests the risk of future coronavirus outbreak caused by spillover infection from animal reservoirs remains high

Indexed as

bispecific inhibitorCOVID-19in vivoMproSARS-CoV-2TMPRSS2

Identifiers

PMID39606435
PMCPMC11601862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.