ArticlemedRxiv : the preprint server for health sciences2024
DNA Methylation Signatures of Cardiovascular Health Provide Insights into Diseases.
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Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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48 authors.
Madeleine CarbonneauPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.ORCID 0009-0002-4102-5952
Yi LiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.ORCID 0000-0002-5544-750X
Yishu QuDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Chicago, IL 60611, USA.
Yinan ZhengDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Chicago, IL 60611, USA.ORCID 0000-0002-2006-7320
Alexis C WoodUnited States Department of Agriculture (USDA)/ARS Children's Nutrition Research Center, Baylor College of Medicine, TX, USA.ORCID 0000-0001-7616-2119
Mengyao WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Chunyu LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.ORCID 0000-0002-9160-0153
Tianxiao HuanPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Roby JoehanesPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-5549-9054
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.ORCID 0000-0002-5264-5068
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.ORCID 0000-0002-8822-0651
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.ORCID 0000-0002-2756-4370
Russell P TracyDepartment of Pathology & Laboratory Medicine, University of Vermont Larner College of Medicine, 360 South Park Drive, Colchester, VT 05446, USA.ORCID 0000-0002-0080-2420
Durda PeterDepartment of Pathology & Laboratory Medicine, University of Vermont Larner College of Medicine, 360 South Park Drive, Colchester, VT 05446, USA.
Yongmei LiuDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
W Craig JohnsonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3161-3753
Wendy S PostDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, USA.ORCID 0000-0002-8655-5204
Tom BlackwellDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.ORCID 0000-0001-7191-1723
Stephen S RichDepartment of Genome Sciences, University of Virginia School of Medicine, 1200 Jefferson Park Avenue, Charlottesville, VA 22903, USA.ORCID 0000-0003-3872-7793
Susan RedlineDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham & Women's Hospital & Harvard Medical School, Boston, MA, 02115, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, TX 77030, USA.ORCID 0000-0003-0677-8158
Jun WangDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Chicago, IL 60611, USA.
Hongyan NingDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Chicago, IL 60611, USA.ORCID 0000-0003-1157-6614
Lifang HouDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Chicago, IL 60611, USA.ORCID 0000-0003-4877-0031
Donald Lloyd-JonesDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Chicago, IL 60611, USA.ORCID 0000-0003-0847-6110
Kendra FerrierDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Aurora, CO 80045, USA.
Yuan-I MinDepartment of Medicine, University of Mississippi Medical Center, 350 W. Woodrow Wilson Avenue, Suite 701, Jackson, MS 39213, USA.ORCID 0000-0003-2470-0004
April P CarsonDepartment of Medicine, University of Mississippi Medical Center, 350 W. Woodrow Wilson Avenue, Suite 701, Jackson, MS 39213, USA.ORCID 0000-0002-7970-6756
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599, USA.ORCID 0000-0002-7892-193X
Alexander TeumerDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-8309-094X
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Henry VölzkeDZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
Matthias NauckDZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.ORCID 0000-0002-6678-7964
Marcus DörrDZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.ORCID 0000-0001-7471-475X
Arce Domingo-RellosoDepartment of Biostatistics, Columbia University Mailman School of Public Health, New York, NY, USA.ORCID 0000-0001-6928-8290
Amanda FrettsDepartment of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-5358-2345
Maria Tellez-PlazaDepartment of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain.ORCID 0000-0002-3850-1228
Shelley ColePopulation Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA.ORCID 0000-0002-2651-0127
Ana Navas-AcienDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.ORCID 0000-0001-9824-7797
Meng WangNutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA.ORCID 0000-0001-8345-9180
Joanne M MurabitoFramingham Heart Study, Framingham, MA.ORCID 0000-0002-0192-7516
Nancy L Heard-CostaDepartment of Medicine, Section of General Internal Medicine Boston University Chobanian & Avedisian School of Medicine, Boston, MA and Boston Medical Center, Boston, MA.ORCID 0000-0001-9730-0306
Brenton PrescottSection of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA.ORCID 0000-0002-3805-9070
Vanessa XanthakisFramingham Heart Study, Framingham, MA.ORCID 0000-0002-7352-621X
Dariush MozaffarianNutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA.ORCID 0000-0001-7958-9492
Daniel LevyPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-1843-8724
Jiantao MaNutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA.ORCID 0000-0001-7478-7203
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTrue Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven N. Chillrud · 1998 to 2026
$44.7MTranslational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MThe Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MPulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHGRI NIH HHS U54 HG003067NHLBI NIH HHS 75N92019D00027NHLBI NIH HHS 75N92019D00028NHLBI NIH HHS 75N92019D00029NHLBI NIH HHS 75N92019D00030NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92023D00002NHLBI NIH HHS 75N92023D00003NHLBI NIH HHS 75N92023D00004NHLBI NIH HHS 75N92023D00005NHLBI NIH HHS 75N92023D00006NHLBI NIH HHS K22 HL135075NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL090863NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL109282NHLBI NIH HHS R01 HL109284NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R01 HL109315NHLBI NIH HHS R01 HL109319NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL155569NHLBI NIH HHS RC1 HL100543NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NHLBI NIH HHS U01 HL120393NIAAA NIH HHS R01 AA028263NIDDK NIH HHS P30 DK063491NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P42 ES033719NIEHS NIH HHS R01 ES021367NIEHS NIH HHS R01 ES025216NIEHS NIH HHS R01 ES032638
Abstract
Background: The association of overall cardiovascular health (CVH) with changes in DNA methylation (DNAm) has not been well characterized. Methods: We calculated the American Heart Association's Life's Essential 8 (LE8) score to reflect CVH in five cohorts with diverse ancestry backgrounds. Epigenome-wide association studies (EWAS) for LE8 score were conducted, followed by bioinformatic analyses. DNAm loci significantly associated with LE8 score were used to calculate a CVH DNAm score. We examined the association of the CVH DNAm score with incident CVD, CVD-specific mortality, and all-cause mortality. Results: We identified 609 CpGs associated with LE8 score at false discovery rate (FDR) < 0.05 in the discovery analysis and at Bonferroni corrected Conclusions: We identified new DNAm signatures for CVH across diverse cohorts. Our analyses indicate that immune response-related pathways may be the key mechanism underpinning the association between CVH and clinical outcomes.
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