Evidence map›Paper›PMID 39606340›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Loss of

Mary Pat Reeve, Stephanie Loomis, Eija Nissilä, Tobias Rausch, Zhili Zheng, Pietro Della Briotta Parolo, Daniel Ben-Isvy, Elias Aho, Emilia Cesetti, Yoko Okunuki and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Mary Pat ReeveInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0003-1788-2321
Stephanie LoomisResearch and Development, Biogen Inc., Cambridge, MA, USA.ORCID 0000-0002-7478-1538
Eija NissiläDepartment of Bacteriology and Immunology, Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Tobias RauschEuropean Molecular Biological Laboratories (EMBL), Heidelberg, Germany.ORCID 0000-0001-5773-5620
Zhili ZhengAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Pietro Della Briotta ParoloAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Daniel Ben-IsvyProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Elias AhoDepartment of Bacteriology and Immunology, Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Emilia CesettiDepartment of Bacteriology and Immunology, Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Yoko OkunukiResearch and Development, Biogen Inc., Cambridge, MA, USA.
Helen McLaughlinResearch and Development, Biogen Inc., Cambridge, MA, USA.
Johanna MäkeläFinnish Biobank Cooperative (FinBB), Turku, Finland.
FinnGen
Mitja KurkiInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Michael E TalkowskiProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Jan O KorbelEuropean Molecular Biological Laboratories (EMBL), Heidelberg, Germany.
Kip ConnorResearch and Development, Biogen Inc., Cambridge, MA, USA.
Seppo MeriDepartment of Bacteriology and Immunology, Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Mark J DalyInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-0949-8752
Heiko RunzInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-2133-7345

Funding

The Genome Aggregation Database (gnomAD)U24HG011450 · NHGRI · BROAD INSTITUTE, INC. · PI Mark Joseph Daly, Konrad Karczewski · 2021 to 2026
$22.3M
Scalable tool and comprehensive maps to interpret structural variation across the neuropsychiatric spectrumR01MH115957 · NIMH · BROAD INSTITUTE, INC. · PI TALKOWSKI, MICHAEL E · 2019 to 2025
$5.4M
Scalable tools and comprehensive maps to interpret structural variation across the neuropsychiatric spectrumR56MH115957 · NIMH · BROAD INSTITUTE, INC. · PI TALKOWSKI, MICHAEL E · 2018 to 2018
$870k
NHGRI NIH HHS U24 HG011450NIMH NIH HHS R01 MH115957NIMH NIH HHS R56 MH115957
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is a prevalent cause of vision loss in the elderly with limited therapeutic options. A single chromosomal region around the complement factor H gene (

Identifiers

PMID39606340
PMCPMC11601675

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.