ArticlemedRxiv : the preprint server for health sciences2024
Characterization of the Subclinical Perilesional Zone in the Macula of Early-Stage ABCA4 Disease.
Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To characterize photoreceptor layer thinning in clinically unremarkable regions adjacent to the atrophic lesion in early-stage ABCA4 disease eyes. Methods: 27 patients with confined atrophic lesions (≤ 3.5mm in diameter) were included. Two pathogenic alleles were confirmed by sequencing of the Results: Conclusion: A uniform subclinical perilesional zone (SPZ) of photoreceptor thinning extends around the perimeter of early-stage atrophic lesions in ABCA4 disease. This region spatially maps to known regions of vision loss and more accurately approximates the extent of photoreceptor abnormality compared to the disease changes visible on standard fundus imaging. Translational relevance: Semi-automated segmentation of SD-OCT scans identifies a consistent subclinical biomarker relevant to early photoreceptor degeneration in ABCA4 disease.
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