Evidence map›Paper›PMID 39606181›Full record

ArticleJournal of the Endocrine Society2024

Oxytocin Receptor Polymorphism Is Associated With Sleep Apnea Symptoms.

Hisanori Goto, Yasuhiko Yamamoto, Hiromasa Tsujiguchi, Takehiro Sato, Reina Yamamoto, Yumie Takeshita, Yujiro Nakano, Takayuki Kannon, Kazuyoshi Hosomichi, Keita Suzuki and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Hisanori GotoDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8640, Japan.ORCID https://orcid.org/0009-0008-4723-6156
Yasuhiko YamamotoDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8640, Japan.
Hiromasa TsujiguchiDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City 920-8640, Japan.
Takehiro SatoDepartment of Human Biology and Anatomy, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903-0215, Japan.
Reina YamamotoDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8640, Japan.
Yumie TakeshitaDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8640, Japan.ORCID https://orcid.org/0000-0002-0475-1931
Yujiro NakanoDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8640, Japan.
Takayuki KannonDepartment of Biomedical Data Science, School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Kazuyoshi HosomichiLaboratory of Computational Genomics, School of Life Science, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.
Keita SuzukiAdvanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan.ORCID https://orcid.org/0000-0003-2833-4080
Masaharu NakamuraDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City 920-8640, Japan.
Yasuhiro KambayashiDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City 920-8640, Japan.
Jiaye ZhaoDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City 920-8640, Japan.
Atsushi AsaiAdvanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan.
Koji KatanoAdvanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan.
Aya OgawaDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City 920-8640, Japan.
Shinobu FukushimaDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City 920-8640, Japan.
Aki ShibataDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City 920-8640, Japan.
Fumihiko SuzukiDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City 920-8640, Japan.
Hirohito TsuboiDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City 920-8640, Japan.
Akinori HaraDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City 920-8640, Japan.ORCID https://orcid.org/0000-0002-0399-1474
Mitsuhiro KometaniDepartment of Health Promotion and Medicine of the Future, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8640, Japan.ORCID https://orcid.org/0000-0003-0461-3018
Shigehiro KarashimaInstitute of Liberal Arts and Science, Kanazawa University, Kanazawa 920-1192, Japan.ORCID https://orcid.org/0000-0002-4084-9653
Takashi YonedaDepartment of Health Promotion and Medicine of the Future, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8640, Japan.
Atsushi TajimaDepartment of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan.ORCID https://orcid.org/0000-0001-6808-5491
Hiroyuki NakamuraDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City 920-8640, Japan.
Toshinari TakamuraDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8640, Japan.ORCID https://orcid.org/0000-0002-4393-3244

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Oxytocin supplementation improves obstructive sleep apnea (OSA), and animal studies suggest involvement of oxytocin in respiratory control. However, the relationship between endogenous oxytocin signaling and human sleep status remains undetermined. Objective: In this study, we approached the contribution of the intrinsic oxytocin-oxytocin receptor (OXTR) system to OSA by genetic association analysis. Methods: We analyzed the relationship between Results: The OXTR rs2254298 A allele was more frequent in those with OSA symptoms than in those without ( Conclusion: The OXTR gene may contribute to OSA symptoms via the respiratory control system, although it could be in linkage disequilibrium with a true causal gene.

Indexed as

genetic association studyobstructive sleep apneaoxytocinoxytocin receptor

Identifiers

PMID39606181
PMCPMC11590662

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.