Evidence map›Paper›PMID 39606167›Full record

ArticleWorld journal of hepatology2024

Reliability of neutrophil gelatinase-associated lipocalin in detecting acute tubular necrosis in decompensated cirrhosis: Systematic review and meta-analysis.

Nirav Agrawal, Scarlet Louis-Jean, Zoya Ladiwala, Harsha Adnani, Ayesha Kamal, Mitchell Karpman, Albert Steven Fleisher, Sanmeet Singh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nirav AgrawalDepartment of Internal Medicine, Anne Arundel Medical Center, Annapolis, MD 21401, United States. nirav1191@gmail.com.
Scarlet Louis-JeanDepartment of Internal Medicine, Anne Arundel Medical Center, Annapolis, MD 21401, United States.
Zoya LadiwalaDepartment of Internal Medicine, Anne Arundel Medical Center, Annapolis, MD 21401, United States.
Harsha AdnaniDepartment of Internal Medicine, Anne Arundel Medical Center, Annapolis, MD 21401, United States.
Ayesha KamalDepartment of Internal Medicine, Anne Arundel Medical Center, Annapolis, MD 21401, United States.
Mitchell KarpmanDepartment of Biostatistics, Anne Arundel Medical Center, Annapolis, MD 21401, United States.
Albert Steven FleisherDepartment of Gastroenterology, Anne Arundel Medical Center, Annapolis, MD 21401, United States.
Sanmeet SinghDepartment of Gastroenterology, Anne Arundel Medical Center, Annapolis, MD 21401, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) in cirrhosis is common. The diagnosis of AKI in cirrhosis patients depends on clinical presentation and laboratory tests like serum creatinine. However, urine biomarkers could also be used to assess the type of AKI and the severity of the disease. We performed a systematic review with meta-analysis to evaluate the association with urine neutrophil gelatinase-associated lipocalin (NGAL) marker in identifying acute tubular necrosis (ATN) in patients with cirrhosis.

aimTo assess the reliability of urine NGAL in the detection of ATN in patients with cirrhosis.

methodsWe systematically searched MEDLINE and PubMed using keywords including "urine biomarkers", "NGAL", "kidney dysfunction", and "cirrhosis" to identify relevant studies. Data was screened and extracted. Included studies assessed hospitalized cirrhosis patients with AKI using the urine NGAL biomarker. We synthesized the data using diagnostic odds ratio (DOR), comparative and descriptive analyses, and Cochran Mantel-Haenszel (CMH) statistics to evaluate heterogeneity.

resultsThree thousand seven hundred and one patients with cirrhosis were analyzed from a total of 21 cohort studies. The DOR of 14 of those studies [pooled DOR: 22.150, (95%CI: 17.58-27.89),

conclusionIn patients with cirrhosis, the use of urine NGAL is a reliable biomarker for detecting ATN and identifying the etiology of AKI.

Indexed as

Acute kidney injuryAcute tubular necrosisBiomarkerCirrhosisNeutrophil gelatinase-associated lipocalinSevere liver dysfunction

Identifiers

PMID39606167
PMCPMC11586751

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