ArticleFrontiers in aging neuroscience2024
Association of dementia with the 28-day mortality of sepsis: an observational and Mendelian randomization study.
Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Clinically recognized sepsis in older adults admitted to medical wards: patient characteristics and hospital outcomes from the REPOSI register.Internal and emergency medicine · 2026Article
- Serum vitamin B12 levels and 90-day outcomes in hospitalized patients with dementia: A cohort study.Medicine · 2026Article
- Development and external validation of a 90-day mortality prediction model for comatose sepsis patients: impact of cerebrovascular disease and dementia.Frontiers in medicine · 2026Article
- Association between zinc deficiency and adverse outcomes in patients with dementia: a matched cohort study.Frontiers in nutrition · 2026Article
- Unsupervised clustering based on a graph attention network reveals high-risk subgroups among ICU dementia patients for enhanced mortality prediction.European journal of medical research · 2025Article
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6 authors.
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Abstract
Background: Observational research suggests that individuals with dementia who have sepsis face a higher likelihood of death. However, whether there is a causal relationship between the two remains unknown. Methods: We analyzed data from patients diagnosed with sepsis and dementia, extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. To examine the correlation between dementia and 28-day mortality in sepsis, we utilized Cox proportional hazards models. Following this, we performed a Mendelian randomization (MR) study with two samples to investigate the potential link between dementia and mortality within 28 days in sepsis. Results: This study included a total of 22,189 patients diagnosed with sepsis, among whom 1,346 cases (6.1%) had dementia. After adjusting for multiple confounding factors, dementia was associated with an increased risk of 28-day mortality in sepsis (HR = 1.25, 95% CI = 1.12-1.39, Conclusion: In the observational analysis, dementia was associated with an increased risk of 28-day mortality in septic patients. However, in the MR analysis, only DLB was associated with increased 28-day mortality in septic patients, with no observed correlation for other dementia subtypes.
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