Evidence map›Paper›PMID 39606008›Full record

ArticleCurrent opinion in physiology2022

Mitochondrial lysine acylation and cardiometabolic stress: Truth or consequence?

Deborah M Muoio, Ashley S Williams, Paul A Grimsrud

Abstract read
In one paragraph

Article in Current opinion in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Deborah M MuoioSarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute.
Ashley S WilliamsSarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute.
Paul A GrimsrudSarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute.

Funding

Role of Carnitine Acetyltransferase in Mitochondrial and Metabolic FunctionR01DK089312 · NIDDK · DUKE UNIVERSITY · PI DEBORAH M MUOIO · 2010 to 2026
$7.8M
Probing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing HeartR01HL128349 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUOIO, DEBORAH M · 2016 to 2024
$6.1M
Mitochondrial Protein Acetylation and Energy Metabolism in MuscleF32DK105922 · NIDDK · DUKE UNIVERSITY · PI WILLIAMS, ASHLEY SILBERMAN · 2015 to 2017
$163k
NHLBI NIH HHS R01 HL128349NIDDK NIH HHS F32 DK105922NIDDK NIH HHS R01 DK089312
6 · The paper itself

Abstract

Disruptions in oxidative metabolism are often accompanied by tissue accumulation of catabolic carbon intermediates, including acyl CoA molecules that can react with the epsilon amino group of lysine residues on cellular proteins. In general, acyl-lysine post-translational modifications (PTMs) on mitochondrial proteins correlate negatively with energy homeostasis and are offset by the mitochondrial sirtuins, a prominent family of NAD

Identifiers

PMID39606008
PMCPMC11601992

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.