Evidence map›Paper›PMID 39605979›Full record

ArticleFrontiers in cell and developmental biology2024

Enhanced T-cell activation and chemokine-associated function in CD14-positive cells from venous sinus blood in sub-acute cerebral venous sinus thrombosis.

Yu-Zhou Chang, Yu-Qi Song, Hao-Yu Zhu, Jia-Rui Zhang, Xi-Guang Fu, Yi-Long Wang, Ke-Hui Dong, Chu-Han Jiang, Da-Peng Mo, Yu-Peng Zhang

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Article in Frontiers in cell and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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5 · Who and what money

Authors and funding

10 authors.

Yu-Zhou Chang *Department of Neurosurgery, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yu-Qi Song *Department of Neurosurgery, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hao-Yu Zhu *Department of Neurosurgery, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jia-Rui ZhangDepartment of Neurosurgery, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xi-Guang FuDepartment of Neurosurgery, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yi-Long WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ke-Hui DongDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Chu-Han JiangDepartment of Neurosurgery, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Da-Peng MoInterventional Neuroradiology Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yu-Peng ZhangDepartment of Neurosurgery, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with sub-acute cerebral venous sinus thrombosis experience (SA.CVST) severe symptoms compared to two other venous sinus-related diseases, including chronic cerebral venous sinus thrombosis (C.CVST) and idiopathic intracranial hypertension (IIH). Objective: This study aimed to determine whether the different immune reactions in different venous sinuses are related. Methods: Stagnant blood in the cerebral venous sinuses was extracted by passing a microcatheter and Results: Compared to patients with IIH, 128 genes were significantly down-regulated and 373 genes were significantly up-regulated in the sub-acute CVST samples. The functions of these genes were mainly focused on "immune response", "T cell activation" and "plasma membrane". Gene Set Enrichment Analysis (GSEA) showed T cell survival and activation-related function significantly unregulated in sub-acute CVST. On the other hand, there were 366 genes down-regulated in chronic CVST and 75 genes up-regulated in chronic CVST. In functional annotation, these differently expressed genes were enriched in the "extracellular region", "chemokine-mediated signaling pathway" and "immune response". GSEA analysis confirmed that chemokine-related functions were all up-regulated in sub-acute CVST and monocyte-macrophage adhesion functions were also significantly up-regulated. Conclusion: This study suggested the

Indexed as

CD14-positive cell sortingcerebral venous sinus thrombosischemokine-mediated signaling pathwayidiopathic intracranial hypertensionT cell activation

Identifiers

PMID39605979
PMCPMC11599252

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