Evidence map›Paper›PMID 39605958›Full record

ArticleFrontiers in chemistry2024

Chemical characterization of wheat-based waste derived from a pharmaceutical process for its potential valorization.

Lidia Ciriaco, Luana Izzo, Giulia Graziani, Maria Grazia Ferraro, Marialuisa Piccolo, Roberto Ciampaglia, Barbara Maglione, Roberta Palladino, Simone Albarella, Eugenia Romano and 3 more

Abstract read
In one paragraph

Article in Frontiers in chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lidia CiriacoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Luana IzzoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Giulia GrazianiDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Maria Grazia FerraroDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.
Marialuisa PiccoloBioChem Lab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Roberto CiampagliaDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Barbara MaglioneFarmaceutici Damor, Naples, Italy.
Roberta PalladinoFarmaceutici Damor, Naples, Italy.
Simone AlbarellaFarmaceutici Damor, Naples, Italy.
Eugenia RomanoFarmaceutici Damor, Naples, Italy.
Alberto RitieniDepartment of Pharmacy, University of Naples Federico II, Naples, Italy.
Carlo IraceBioChem Lab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Paolo GriecoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We report the analysis and characterization and the preliminary biological evaluation, of both liquid and solid wastes obtained from the processing of wheat ( Methods: In this perspective, we first carried out an in-depth chemical-physical analysis of the waste together with a biocompatibility evaluation to plan the feasible final choice of waste destination. The liquid and solid waste derived from the processing of wheat extract were analyzed and characterized through ultra-high-performance liquid chromatography coupled with high-resolution Orbitrap mass spectrometry (UHPLC-Q-Orbitrap HRMS). Results: Results highlight that ferulic acid represent the most abundant phenolic compound for solid waste with a content of 89.782 mg/kg and dihydroferulic acid is the predominant for liquid waste (6.24 mg/L). These concentrations represent 55.87% and 84.39% of the total concentration of bioactive compounds for liquid and solid waste, respectively. The antioxidant activity registered for the solid extract was 8.598 and 7.262 mmol trolox/kg, respectively for ABTS and FRAP assays. The total phenolic content (TPC) in the liquid extract undergoes a significant percentage reduction compared to the solid waste. As regards toxicity, both liquid and solid wastes were investigated Discussion: Overall, considering its chemo-physical features and active ingredients, we believe that this waste is highly reusable as a starting material for the development of cosmeceutical products. Thus, this study allows us to motivate the destination of the waste of the production in a recyclable raw material for additional industrial processes, thereby promoting an eco-friendly circular economy operation.

Indexed as

bioactive compoundsbiocompatibilitypharmaceutical wasteTriticum vulgareUHPLC Q-orbitrap HRMSupcycling

Identifiers

PMID39605958
PMCPMC11601129

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.