Palladium Catalyzed Allylic C-H Oxidation Enabled by Bicyclic Sulfoxide Ligands.

Yuming Wen, Jianfeng Zheng, Alex H Evans, Qiang Zhang

Abstract read

In one paragraph

Article in Organics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Reversible Conjugation of Polypeptides and Proteins Utilizing a [3.3.1] Scaffold under Mild Conditions.Organic letters · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuming WenDepartment of Chemistry, University at Albany, State University of New York, Albany, NY 12222, USA.

Jianfeng ZhengDepartment of Chemistry, University at Albany, State University of New York, Albany, NY 12222, USA.

Alex H EvansDepartment of Chemistry, University at Albany, State University of New York, Albany, NY 12222, USA.

Qiang ZhangDepartment of Chemistry, University at Albany, State University of New York, Albany, NY 12222, USA.

Funding

The chemical approach towards homogenous glycoprotein preparation and evaluationR35GM138336 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Qiang Zhang · 2020 to 2026

$2.2M

NIGMS NIH HHS R35 GM138336

6 · The paper itself

Abstract

The activation of C-H bonds is a potent tool for modifying molecular structures in chemistry. This article details the steps involved in a novel ligand bearing a bicyclic [3.3.1]-nonane framework and bissulfoxide moiety. A palladium catalyzed allylic C-H oxidation method enables a direct benzyl-allylic functionalization with the bissulfoxide ligand. Bissulfoixde ligand possesses a rapidly constructed bicyclic [3.3.1] framework and it proved to be effective for enabling both N-and C-alkylation. A total of 13 C-H activation productions were reported with good to excellent yields. This report validated that it is necessary to include bissulfoxide as a ligand for superior reactivities. Naftifine was produced utilizing developed C-H functionalization methodology in good overall yields.

Indexed as

amino acidsbicyclic ligandC-H activationpalladiumsulfoxide

Identifiers

PMID39605929

DOI10.3390/org4020023

PMCPMC11601123

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.