Evidence map›Paper›PMID 39605892›Full record

ArticleFrontiers in oncology2024

Case report: The effect of induction targeted therapies in stage III driver mutants non-small cell lung cancer.

Waleed Kian, Belal Krayim, Betsy Giles, Nasim A Elkiaan, Amjad Idris, Daniel Fink, Nir Peled, Laila C Roisman

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Waleed Kian *Helmsley Cancer Center, Shaare Zedek Medical Center, Jerusalem, Israel.
Belal Krayim *Helmsley Cancer Center, Shaare Zedek Medical Center, Jerusalem, Israel.
Betsy GilesBen-Gurion University of the Negev, Be'er Sheva, Israel.
Nasim A ElkiaanBen-Gurion University of the Negev, Be'er Sheva, Israel.
Amjad IdrisThoracic Surgery Department, Shaare Zedek Medical Center, Jerusalem, Israel.
Daniel FinkThoracic Surgery Department, Shaare Zedek Medical Center, Jerusalem, Israel.
Nir PeledHelmsley Cancer Center, Shaare Zedek Medical Center, Jerusalem, Israel.
Laila C RoismanHelmsley Cancer Center, Shaare Zedek Medical Center, Jerusalem, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Over the past decade, progress in the diagnosis and treatment of Non-Small Cell Lung Cancer (NSCLC) has led to the identification of many targeted mutations. This has enhanced PFS and OS in both advanced and early-stage NSCLC. The current standard of care for stage III NSCLC varies, and it may combine chemotherapy with either immunotherapy or radiotherapy. This study evaluated the role of induction targeted therapies in patients with driver mutations and inoperable NSCLC. Methods: This is a single-center, retrospective study assessing the efficacy of targeted therapy in resectable stage III NSCLC patients who are Results: Between January 2020 and February 2024, we identified four patients with either Conclusions: This case series highlights the potential of targeted therapies for resectable NSCLC in the neoadjuvant setting. Further research is required to confirm their benefits, assess their safety and efficacy, and determine optimal timing and sequencing.

Indexed as

ALKbrigatinibEGFRlung cancerneoadjuvantosimertinib

Identifiers

PMID39605892
PMCPMC11598925

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.