Evidence map›Paper›PMID 39605737›Full record

ArticlebioRxiv : the preprint server for biology2024

Schistosome esophageal gland factor MEG-8.2 drives host cell lysis and interacts with host immune proteins.

Pallavi Yadav, Sabona B Simbassa, Ryan Sloan, Phillip A Newmark, Jayhun Lee

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Pallavi YadavDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.
Sabona B SimbassaMicrobiology and Infectious Diseases Program, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX 77030.
Ryan SloanMicrobiology and Infectious Diseases Program, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX 77030.
Phillip A NewmarkHoward Hughes Medical Institute, Morgridge Institute for Research, Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI 53715.ORCID 0000-0003-0793-022X
Jayhun LeeDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.ORCID 0000-0003-3967-3424

Funding

Esophageal gland-mediated immune evasion by the human parasite Schistosoma mansoniR01AI175079 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LEE, JAYHUN · 2023 to 2025
$2.1M
NIAID NIH HHS HHSN272201700014CNIAID NIH HHS R01 AI175079
6 · The paper itself

Abstract

Schistosomes are blood flukes that ingest large amounts of host blood during their intra-mammalian stage. The ingested blood contains leukocytes that can be harmful, yet the parasites survive inside the host for decades, reflecting superb immune evasion mechanisms that remain poorly understood. Our previous work discovered that FoxA, a forkhead transcription factor, drives the production of the esophageal gland, an anterior digestive organ essential for degrading the ingested leukocytes and for

Identifiers

PMID39605737
PMCPMC11601278

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.