Evidence map›Paper›PMID 39605729›Full record

ArticlebioRxiv : the preprint server for biology2024

Perspectives on Codebook: sequence specificity of uncharacterized human transcription factors.

Arttu Jolma, Kaitlin U Laverty, Ali Fathi, Ally W H Yang, Isaac Yellan, Ilya E Vorontsov, Sachi Inukai, Judith F Kribelbauer-Swietek, Antoni J Gralak, Rozita Razavi and 17 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Arttu JolmaDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.ORCID 0000-0002-2543-7490
Kaitlin U LavertyDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.ORCID 0009-0004-4341-4665
Ali FathiDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.ORCID 0009-0007-1441-9653
Ally W H YangDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.ORCID 0000-0002-8678-0946
Isaac YellanDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.ORCID 0000-0001-6622-1189
Ilya E VorontsovVavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia.ORCID 0000-0001-8888-0804
Sachi InukaiLaboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.ORCID 0000-0002-6404-1384
Judith F Kribelbauer-SwietekLaboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.ORCID 0000-0002-8072-7773
Antoni J GralakLaboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.ORCID 0009-0007-1086-6165
Rozita RazaviDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.ORCID 0009-0000-5466-6519
Mihai AlbuDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Alexander BrechalovDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Zain M PatelDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Vladimir NozdrinFaculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991, Moscow, Russia.
Georgy MeshcheryakovInstitute of Protein Research, Russian Academy of Sciences, 142290, Pushchino, Russia.ORCID 0000-0003-0751-8286
Ivan KozinInstitute of Protein Research, Russian Academy of Sciences, 142290, Pushchino, Russia.ORCID 0009-0009-4603-8550
Sergey AbramovVavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia.ORCID 0000-0002-3334-5334
Alexandr BoytsovVavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia.ORCID 0000-0002-2712-8368
Codebook Consortium
Oriol FornesDepartment of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.ORCID 0000-0002-5969-3054
Vsevolod J MakeevVavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia.ORCID 0000-0001-9405-9748
Jan GrauInstitute of Computer Science, Martin Luther University Halle-Wittenberg, 06099, Halle, Germany.ORCID 0000-0003-2081-6405
Ivo GrosseInstitute of Computer Science, Martin Luther University Halle-Wittenberg, 06099, Halle, Germany.ORCID 0000-0001-5318-4825
Philipp BucherSwiss Institute of Bioinformatics, 1015, Lausanne, Switzerland.
Bart DeplanckeLaboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.ORCID 0000-0001-9935-843X
Ivan V KulakovskiyVavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia.ORCID 0000-0002-6554-8128
Timothy R HughesDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.ORCID 0000-0002-8721-4719

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7M
Gene regulatory network modeling of disease-associated DNA methylation perturbationsR01AI173314 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Minji Byun, Emily Miraldi · 2023 to 2026
$3.1M
Post-transcriptional Regulatory NetworksR01HG013328 · NHGRI · SLOAN-KETTERING INST CAN RESEARCH · PI Quaid Morris · 2023 to 2026
$2.6M
Transcription Factor Genetics in LupusR01AR073228 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI KOTTYAN, LEAH CLAIRE, WAGGONER, STEPHEN N. · 2019 to 2023
$2.2M
CisBP and CisBP-RNA: web resources for protein-DNA and protein-RNA binding modelsU24HG013078 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI Matthew Tyson Weirauch · 2024 to 2026
$1.6M
Measuring and describing nucleosome remodeler sequence preferencesR21HG012258 · NHGRI · UNIVERSITY OF TORONTO · PI HUGHES, TIMOTHY · 2022 to 2022
$267k
NCI NIH HHS P30 CA008748NHGRI NIH HHS R01 HG013328NHGRI NIH HHS R21 HG012258NHGRI NIH HHS U24 HG013078NIAID NIH HHS R01 AI173314NIAMS NIH HHS P30 AR070549NIAMS NIH HHS R01 AR073228
6 · The paper itself

Abstract

We describe an effort ("Codebook") to determine the sequence specificity of 332 putative and largely uncharacterized human transcription factors (TFs), as well as 61 control TFs. Nearly 5,000 independent experiments across multiple

Indexed as

ChIP-seqCodebookDNA-binding specificityGHT-SELEXHT-SELEXMotifPBMPWMSELEXSMiLE-seqTFTranscription factor

Identifiers

PMID39605729
PMCPMC11601247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.