Evidence map›Paper›PMID 39605726›Full record

ArticlebioRxiv : the preprint server for biology2024

Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state.

Mary C Rominger, Saksham Gupta, Sitapriya Moorthi, Maria McSharry, Shriya Kamlapurkar, Siobhan O'Brien, Annie Waldum, April Lo, Fujiko Duke, Amy R Lowe and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Mary C RomingerHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Saksham GuptaHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Sitapriya MoorthiHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Maria McSharryHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Shriya KamlapurkarHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Siobhan O'BrienHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Annie WaldumHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109.
April LoHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Fujiko DukeCancer Biology Program, Broad Institute of MIT & Harvard, Cambridge, MA, 02142.
Amy R LoweHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Elizabeth CromwellPre-clinical Modeling Core, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Raisa GlabmanComparative Pathology, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Amanda KoehneComparative Pathology, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Alice H BergerHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109.ORCID 0000-0002-6538-2658

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Project 4: Risk stratification for pulmonary nodules detected by CT imaging using plasma and imaging biomarkersP50CA228944 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI A McGarry Houghton · 2019 to 2026
$19.6M
Understanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancerR37CA252050 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Alice Berger · 2021 to 2026
$3.1M
Investigating the role of the small GTPase RIT1 in lung adenocarcinomaR00CA197762 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BERGER, ALICE · 2017 to 2019
$747k
NCI NIH HHS P30 CA015704NCI NIH HHS P50 CA228944NCI NIH HHS R00 CA197762NCI NIH HHS R37 CA252050
6 · The paper itself

Abstract

The discovery of oncogene addiction in cancer has led to the development of over a dozen FDA-approved biomarker-driven therapies in lung adenocarcinoma. Somatic mutations of the "Ras-like in all tissues" (RIT1) gene are non-canonical driver events in lung cancer, occurring in ~2% of lung adenocarcinomas in a mutually exclusive fashion with

Identifiers

PMID39605726
PMCPMC11601272

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.