Evidence map›Paper›PMID 39605723›Full record

ArticlebioRxiv : the preprint server for biology2024

APOE Protects Against Severe Infection with

Dong Liu, Dat Mai, Ana N Jahn, Tara A Murray, John D Aitchison, Benjamin H Gern, Kevin B Urdahl, Alan Aderem, Alan H Diercks, Elizabeth S Gold

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Dong LiuCenter for Global Infectious Disease Research, Seattle Children's Research Institute; Seattle, WA 98109, USA.ORCID 0000-0002-1836-2267
Dat MaiCenter for Global Infectious Disease Research, Seattle Children's Research Institute; Seattle, WA 98109, USA.
Ana N JahnCenter for Global Infectious Disease Research, Seattle Children's Research Institute; Seattle, WA 98109, USA.
Tara A MurrayCenter for Global Infectious Disease Research, Seattle Children's Research Institute; Seattle, WA 98109, USA.
John D AitchisonCenter for Global Infectious Disease Research, Seattle Children's Research Institute; Seattle, WA 98109, USA.
Benjamin H GernCenter for Global Infectious Disease Research, Seattle Children's Research Institute; Seattle, WA 98109, USA.ORCID 0000-0002-0142-5970
Kevin B UrdahlCenter for Global Infectious Disease Research, Seattle Children's Research Institute; Seattle, WA 98109, USA.ORCID 0000-0003-0088-1066
Alan AderemCenter for Global Infectious Disease Research, Seattle Children's Research Institute; Seattle, WA 98109, USA.ORCID 0000-0003-4031-5499
Alan H DiercksCenter for Global Infectious Disease Research, Seattle Children's Research Institute; Seattle, WA 98109, USA.ORCID 0000-0002-5236-6130
Elizabeth S GoldCenter for Global Infectious Disease Research, Seattle Children's Research Institute; Seattle, WA 98109, USA.ORCID 0000-0001-6560-6896

Funding

IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) - SARS-CoV-2 RELATED RESEARCH75N93019C00070 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI URDAHL, KEVIN · 2019 to 2025
$86.6M
Technology CoreU19AI135976 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI SHERMAN, DAVID R · 2018 to 2022
$17.0M
NIAID NIH HHS 75N93019C00070NIAID NIH HHS U19 AI135976
6 · The paper itself

Abstract

While neutrophils are the predominant cell type in the lungs of humans with active tuberculosis (TB), they are relatively scarce in the lungs of most strains of mice that are used to study the disease. However, similar to humans, neutrophils account for approximately 45% of CD45+ cells in the lungs of

Identifiers

PMID39605723
PMCPMC11601580

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.