Evidence map›Paper›PMID 39605720›Full record

ArticlebioRxiv : the preprint server for biology2024

Molecular Polymorphism of tau aggregates in Pick's disease.

Jiliang Liu, Theresa Connors Stewart, Bradley T Hyman, Manfred Burghammer, Marine Cotte, Lee Makowski

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jiliang LiuEuropean Synchrotron Radiation Facility, Grenoble 38043, France.ORCID 0000-0002-3491-3452
Theresa Connors StewartDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Bradley T HymanDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.ORCID 0000-0002-7959-9401
Manfred BurghammerEuropean Synchrotron Radiation Facility, Grenoble 38043, France.
Marine CotteEuropean Synchrotron Radiation Facility, Grenoble 38043, France.
Lee MakowskiBioengineering Department, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0003-0202-9264

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5M
Fibrillar polymorphs in human brain tissueRF1AG079946 · NIA · NORTHEASTERN UNIVERSITY · PI MAKOWSKI, LEE · 2023 to 2023
$2.1M
Localization of fibrillar polymorphs in human brain tissueR21AG068972 · NIA · NORTHEASTERN UNIVERSITY · PI MAKOWSKI, LEE · 2020 to 2020
$432k
NIA NIH HHS P30 AG062421NIA NIH HHS R21 AG068972NIA NIH HHS RF1 AG079946
6 · The paper itself

Abstract

Tau protein plays a central role in many neuropathies. The trajectory by which tau spreads through neural networks is disease-specific but the events driving progression are unknown. This is due in part to the challenge of characterizing tau aggregates

Indexed as

Biological SciencesBiophysics and Computational Biologyneurodegenerative diseasetaux-ray fluorescence microscopyx-ray microdiffraction

Identifiers

PMID39605720
PMCPMC11601565

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.