Evidence map›Paper›PMID 39605697›Full record

ArticlebioRxiv : the preprint server for biology2024

Striking Departures from Polygenic Architecture in the Tails of Complex Traits.

Tade Souaiaia, Hei Man Wu, Anil P S Ori, Shing Wan Choi, Clive J Hoggart, Paul F O'Reilly

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tade SouaiaiaDepartment of Cellular Biology, Suny Downstate Health Sciences University, Brooklyn, NY, USA.ORCID 0000-0003-3922-1372
Hei Man WuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, NY, NY, USA.ORCID 0000-0003-1559-7586
Anil P S OriDepartment of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, NY, NY, USA.ORCID 0000-0003-0579-0905
Shing Wan ChoiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, NY, NY, USA.ORCID 0000-0003-2215-3238
Clive J HoggartDepartment of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, NY, NY, USA.ORCID 0000-0002-6875-6993
Paul F O'ReillyDepartment of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, NY, NY, USA.ORCID 0000-0001-7515-0845

Funding

Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Carolyn Wei Zhu · 2020 to 2026
$31.0M
Next-generation, pathway-specific, polygenic risk scoresR01MH122866 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI O'REILLY, PAUL FRANCIS · 2020 to 2024
$3.1M
BridgePRS: bridging the gap in polygenic risk scores between ancestries.R01HG012773 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul Francis O'Reilly · 2023 to 2026
$2.6M
NHGRI NIH HHS R01 HG012773NIA NIH HHS P30 AG066514NIMH NIH HHS R01 MH122866
6 · The paper itself

Abstract

Understanding the genetic architecture of human traits is of key biological, medical and evolutionary importance

Identifiers

PMID39605697
PMCPMC11601658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.