Evidence map›Paper›PMID 39605688›Full record

ArticlebioRxiv : the preprint server for biology2024

Developmental Stage and Cellular Context Determine Oncogenic and Molecular Outcomes of

Sarah M Zimmerman, Samantha J Procasky, Sofia R Smith, Jie-Yu Liu, Chad Torrice, George P Souroullas

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Sarah M ZimmermanDepartment of Medicine.
Samantha J ProcaskyDivision of Oncology, Molecular Oncology Section.
Sofia R SmithDepartment of Medicine.
Jie-Yu LiuUniversity of North Carolina, Chapel Hill, North Carolina, USA.
Chad TorriceUniversity of North Carolina, Chapel Hill, North Carolina, USA.
George P SouroullasDepartment of Medicine.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
MOLECULAR ONCOLOGY TRAINING GRANTT32CA113275 · NCI · WASHINGTON UNIVERSITY · PI Matthew J Walter · 2006 to 2026
$5.7M
Investigate the effect of oncogenic EZH2 mutations on chromatin and cancerK22CA229612 · NCI · WASHINGTON UNIVERSITY · PI SOUROULLAS, GEORGE P. · 2018 to 2020
$504k
NCI NIH HHS K22 CA229612NCI NIH HHS P30 CA091842NCI NIH HHS T32 CA113275
6 · The paper itself

Abstract

Mutations in the histone methyltransferase EZH2, particularly the Y641 hotspot mutation, have been implicated in hematologic malignancies, yet the effect of timing and cellular context on their oncogenic potential has remained unknown. In this study, we utilized a conditional allele with tissue-specific Cre drivers to investigate the effects of

Identifiers

PMID39605688
PMCPMC11601384

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.