Evidence map›Paper›PMID 39605685›Full record

ArticlebioRxiv : the preprint server for biology2024

Accurate

Stephen A Rettie, David Juergens, Victor Adebomi, Yensi Flores Bueso, Qinqin Zhao, Alexandria N Leveille, Andi Liu, Asim K Bera, Joana A Wilms, Alina Üffing and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Heuristic energy-based cyclic peptide design.PLoS computational biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Stephen A RettieDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9797-6939
David JuergensInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6425-8391
Victor AdebomiDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4573-5102
Yensi Flores BuesoDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2118-2195
Qinqin ZhaoDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Alexandria N LeveilleDepartment of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA, USA.ORCID 0000-0002-0534-4828
Andi LiuDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Asim K BeraInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9473-2912
Joana A WilmsHeinrich-Heine-Universität Düsseldorf, Institut für Physikalische Biologie, Düsseldorf, Germany.ORCID 0000-0001-5655-7009
Alina ÜffingHeinrich-Heine-Universität Düsseldorf, Institut für Physikalische Biologie, Düsseldorf, Germany.ORCID 0000-0001-8808-1033
Alex KangInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5487-0499
Evans BrackenbroughInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0009-0004-1476-0219
Mila LambInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7318-1805
Stacey R GerbenInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0003-0313-6248
Analisa MurrayInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0003-1560-6673
Paul M LevineInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4874-5557
Maika SchneiderDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.
Vibha VasireddyDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.
Sergey OvchinnikovDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-2774-2744
Oliver H WeiergräberForschungszentrum Jülich, Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Jülich, Germany.ORCID 0000-0002-2410-3691
Dieter WillboldHeinrich-Heine-Universität Düsseldorf, Institut für Physikalische Biologie, Düsseldorf, Germany.ORCID 0000-0002-0065-7366
Joshua A KritzerDepartment of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA, USA.ORCID 0000-0003-2878-6781
Joseph D MougousDepartment of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5417-4861
David BakerInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7896-6217
Frank DiMaioInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7524-8938
Gaurav BhardwajDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6554-2335

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
De Novo Design of Minibinder Antagonists for COVID-19 and Future PandemicsR01AI160052 · NIAID · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID, FULLER, DEBORAH H. · 2021 to 2025
$3.5M
Diversity Supplement for Imani McDonald - Developing Autophagy-Targeting Chimeras and Optimizing Cell Penetration of Large-Molecule TherapeuticsR35GM148407 · NIGMS · TUFTS UNIVERSITY MEDFORD · PI Joshua A Kritzer · 2023 to 2026
$2.6M
NIAID NIH HHS R01 AI160052NIGMS NIH HHS P30 GM133893NIGMS NIH HHS R35 GM148407
6 · The paper itself

Abstract

The development of macrocyclic binders to therapeutic proteins typically relies on large-scale screening methods that are resource-intensive and provide little control over binding mode. Despite considerable progress in physics-based methods for peptide design and deep-learning methods for protein design, there are currently no robust approaches for

Identifiers

PMID39605685
PMCPMC11601608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.