Evidence map›Paper›PMID 39605667›Full record

ArticlebioRxiv : the preprint server for biology2024

Structural diversity and oligomerization of bacterial ubiquitin-like proteins.

Minheng Gong, Qiaozhen Ye, Yajie Gu, Lydia R Chambers, Andrey A Bobkov, Neal K Arakawa, Mariusz Matyszewski, Kevin D Corbett

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Minheng GongDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla CA 92093.
Qiaozhen YeDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla CA 92093.
Yajie GuDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla CA 92093.
Lydia R ChambersDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla CA 92093.
Andrey A BobkovConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, CA 92037.
Neal K ArakawaEnvironmental and Complex Analysis Laboratory, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla CA 92093.
Mariusz MatyszewskiUC San Diego Cryo-EM Facility, University of California San Diego, La Jolla CA 92093.
Kevin D CorbettDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla CA 92093.ORCID 0000-0001-5854-2388

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
Molecular Biophysics Training Grant at UC San DiegoT32GM139795 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Galia Debelouchina, ELIZABETH A. KOMIVES · 2021 to 2026
$3.0M
Molecular mechanisms of nucleic acid recognition and maintenance in meiosis and innate immunityR35GM144121 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett · 2022 to 2026
$2.7M
Pilatus 6mS10OD021832 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ADAMS, PAUL DAVID · 2016 to 2016
$980k
NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R35 GM144121NIGMS NIH HHS T32 GM139795NIH HHS S10 OD021832
6 · The paper itself

Abstract

Bacteria possess a variety of operons with homology to eukaryotic ubiquitination pathways that encode predicted E1, E2, E3, deubiquitinase, and ubiquitin-like proteins. Some of these pathways have recently been shown to function in anti-bacteriophage immunity, but the biological functions of others remain unknown. Here, we show that ubiquitin-like proteins in two bacterial operon families show surprising architectural diversity, possessing one to three β-grasp domains preceded by diverse N-terminal domains. We find that a large group of bacterial ubiquitin-like proteins possess three β-grasp domains and form homodimers and helical filaments mediated by conserved Ca

Identifiers

PMID39605667
PMCPMC11601603

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.