Evidence map›Paper›PMID 39605654›Full record

ArticlebioRxiv : the preprint server for biology2024

Long-lasting, subtype-specific regulation of somatostatin interneurons during sensory learning.

Mo Zhu, Matthew B Mosso, Xiaoyang Ma, Eunsol Park, Alison L Barth

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Mo ZhuDepartment of Biological Sciences, Carnegie Mellon University; Pittsburgh 15213 U.S.A.ORCID 0000-0002-1235-7993
Matthew B MossoDepartment of Biological Sciences, Carnegie Mellon University; Pittsburgh 15213 U.S.A.ORCID 0000-0002-9270-8692
Xiaoyang MaDepartment of Biological Sciences, Carnegie Mellon University; Pittsburgh 15213 U.S.A.ORCID 0009-0009-6395-3187
Eunsol ParkDepartment of Biological Sciences, Carnegie Mellon University; Pittsburgh 15213 U.S.A.ORCID 0000-0001-9433-4762
Alison L BarthDepartment of Biological Sciences, Carnegie Mellon University; Pittsburgh 15213 U.S.A.ORCID 0000-0001-7092-1356

Funding

Determinants of sparse activity in neocortexR01NS123711 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI ALISON L BARTH · 2022 to 2026
$2.5M
Synaptic plasticity in sensory learningR21NS127354 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI BARTH, ALISON L · 2022 to 2022
$397k
NINDS NIH HHS R01 NS123711NINDS NIH HHS R21 NS127354
6 · The paper itself

Abstract

Somatostatin (SST)-expressing inhibitory neurons are a major class of neocortical γ-amino butyric acid (GABA) neurons, where morphological, electrophysiological, and transcriptomic analyses indicate more than a dozen different subtypes. However, whether this diversity is related to specific roles in cortical computations and plasticity remains unclear. Here we identify learning-dependent, subtype-specific plasticity in layer 2/3 SST neurons of the mouse somatosensory cortex. Martinotti-type, SST neurons expressing calbindin-2 show a selective decrease in excitatory synaptic input and stimulus-evoked calcium responses as mice learn a stimulus-reward association. Using these insights, we develop a label-free classifier using basal activity from

Identifiers

PMID39605654
PMCPMC11601575

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.