Evidence map›Paper›PMID 39605652›Full record

ArticlebioRxiv : the preprint server for biology2024

Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Progression by Enhancing Tight Junction-Controlled Pancreatic Ductal Transport.

Sneha Kesaraju, Yueying Li, Junjie Xing, Melissa Tracy, Kristin Wannemo, Aysha Holder, Piao Zhao, Mohammed Azizuddin Khan, Joseph Kainov, Niyati Rana and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Sneha Kesaraju
Yueying Li
Junjie Xing
Melissa Tracy
Kristin Wannemo
Aysha Holder
Piao Zhao
Mohammed Azizuddin Khan
Joseph Kainov
Niyati Rana
Mohammed Sidahmed
Sanjiv Hyoju
Lexi Smith
Jonathan Matthews
Fatemeh Khalili-AraghiORCID 0000-0002-0756-5560
Maunak Rana
Scott A Oakes
Christopher R WeberORCID 0000-0002-2117-3184

Funding

Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)T32HD007009 · NICHD · UNIVERSITY OF CHICAGO · PI NANCY B SCHWARTZ · 1985 to 2026
$13.0M
Role of Pancreatic Elastase in Beta Cell Health, Autoimmunity and Type 1 DiabetesU01DK143494 · NIDDK · UNIVERSITY OF CHICAGO · PI Mark S Anderson, ROHIT N. KULKARNI · 2025 to 2026
$3.3M
NICHD NIH HHS T32 HD007009NIDDK NIH HHS U01 DK143494
6 · The paper itself

Abstract

Pancreatitis is an inflammatory disease of the pancreas that can arise due to various factors, including environmental risks such as diet, alcohol, and smoking, as well as genetic predispositions. In some cases, pancreatitis may progress and become chronic, leading to irreversible damage and impaired pancreatic function. Genome-wide association studies (GWAS) have identified polymorphisms at the X-linked

Identifiers

PMID39605652
PMCPMC11601259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.