Evidence map›Paper›PMID 39605645›Full record

ArticlebioRxiv : the preprint server for biology2024

Sulfur-species in Zinc-specific Condylar Zones of a Rat Temporomandibular Joint.

Brandon H Lee, Zhiyuan Yang, Tiffany Ho, Yongmei Wang, Nobumichi Tamura, Samuel Webb, Sharon Bone, Sunita P Ho

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Brandon H LeePreventive and Restorative Dent. Sci., San Francisco, CA.ORCID 0000-0002-2656-6876
Zhiyuan YangPreventive and Restorative Dent. Sci., San Francisco, CA.
Tiffany HoPreventive and Restorative Dent. Sci., San Francisco, CA.
Yongmei WangPreventive and Restorative Dent. Sci., San Francisco, CA.
Nobumichi TamuraAdvanced Light Source, Lawrence Berkeley Natl. Lab., Berkeley, CA.
Samuel WebbStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA.
Sharon BoneStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA.
Sunita P HoPreventive and Restorative Dent. Sci., San Francisco, CA.

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
Load-mediated Adaptation of the Bone-PDL-Tooth Complex in VertebratesR01DE022032 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HO, SUNITA P · 2012 to 2021
$3.4M
NIDCR NIH HHS R01 DE022032NIGMS NIH HHS P30 GM133894
6 · The paper itself

Abstract

In this study, we performed synchrotron-based micro-X-ray fluorescence (μ-XRF) imaging of elements Zn and S, and X-ray absorption near edge spectroscopy (XANES) coupled with μ-XRF for identification of Zn and S species in the condylar zones of a rat temporomandibular joint (TMJ). Histologic localization of Zn and hypoxia-inducible factor-1α (HIF-1α) were mapped using an optical microscope. These data were visually correlated with μ-XRF and XANES data to provide insights into plausible biological S-species in Z-enriched condylar zones of a rat TMJ. Furthermore, μ-XRF coupled with micro-X-ray diffraction (μ-XRD) was used to underline Z-incorporated biological apatite in the subchondral bone and bone of the rat TMJ. Results illustrated the potential dependence between biometal Zn and nonmetal S and their collective governance of cell and tissue functions in a zone-specific manner. Elemental Zn with organic and inorganic S-species at the cartilage-bone interface and transformation of plausible Zn-enriched mineralization kinetics of biological apatite from subchondral bone to condylar bone were ascertained using μ-XRF-XANES and μ-XRD. The coupled μ-XRF-XANES complementing with μ-XRD and immunohistology provided an informative view of S and Zn and their association with zone-specific biological pathways

Indexed as

biomineralsosteoarthritisoxidative stressSulfurtemporomandibular jointXANESXRFZinc

Identifiers

PMID39605645
PMCPMC11601290

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.