Evidence map›Paper›PMID 39605638›Full record

ArticlebioRxiv : the preprint server for biology2024

HSP90 buffers deleterious genetic variations in

Brant Gracia, Patricia Montes, Min Huang, Junjie Chen, Georgios Ioannis Karras

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Brant Gracia
Patricia Montes
Min Huang
Junjie Chen
Georgios Ioannis KarrasORCID 0000-0003-2933-1535

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
How HSP90 shapes genotype-phenotype relationships to alter treatment outcome in cancerK22CA222938 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KARRAS, GEORGIOS · 2020 to 2022
$577k
INVESTIGATING THE ROLE OF HSP90 IN SHAPING THE CONSEQUENCES OF BRCA1 MUTATIONSF32CA253780 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GRACIA, BRANT · 2021 to 2023
$216k
NCI NIH HHS F32 CA253780NCI NIH HHS K22 CA222938NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA125123
6 · The paper itself

Abstract

Protein-folding chaperone HSP90 buffers genetic variation in diverse organisms, but the clinical significance of HSP90 buffering in disease remains unclear. Here, we show that HSP90 buffers mutations in the BRCT domain of BRCA1. HSP90-buffered

Identifiers

PMID39605638
PMCPMC11601394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.