Evidence map›Paper›PMID 39605636›Full record

ArticlebioRxiv : the preprint server for biology2024

Mapping Pesticide-Induced Metabolic Alterations in Human Gut Bacteria.

Li Chen, Hong Yan, Shanshan Di, Chao Guo, Huan Zhang, Shiqi Zhang, Andrew Gold, Yu Wang, Ming Hu, Dayong Wu and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Li ChenHuman Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
Hong YanDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.
Shanshan DiState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products/ Key Laboratory of Detection for Pesticide Residues and Control of Zhejiang, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
Chao GuoHuman Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
Huan ZhangHuman Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
Shiqi ZhangHuman Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
Andrew GoldHuman Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
Yu WangDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Ming HuHuman Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
Dayong WuDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Caroline H JohnsonDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.
Xinquan WangState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products/ Key Laboratory of Detection for Pesticide Residues and Control of Zhejiang, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
Jiangjiang ZhuHuman Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.

Funding

Characterizing the Metabolome and Volatilome of Gut MicrobiomeR35GM133510 · NIGMS · OHIO STATE UNIVERSITY · PI ZHU, JIANGJIANG · 2019 to 2023
$2.2M
NIGMS NIH HHS R35 GM133510
6 · The paper itself

Abstract

Pesticides can modulate gut microbiota (GM) composition, but their specific effects on GM remain largely elusive. Our study demonstrated that pesticides inhibit or promote growth in various GM species, even at low concentrations, and can accumulate in GM to prolong their presence in the host. Meanwhile, the pesticide induced changes in GM composition are associated with significant alterations in gut bacterial metabolism that reflected by the changes of hundreds of metabolites. We generated a pesticide-GM-metabolites (PMM) network that not only reveals pesticide-sensitive gut bacteria species but also report specific metabolic changes in 306 pesticide-GM pairs (PGPs). Using an

Indexed as

Gut bacteriaInflammationLipidomicsMetabolomicsPesticide

Identifiers

PMID39605636
PMCPMC11601348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.