Evidence map›Paper›PMID 39605628›Full record

ArticlebioRxiv : the preprint server for biology2024

PFAS Compounds PFOA and Gen X are Teratogenic to Sea Urchin Embryos.

Alexandra T Lion, Sophie M Bodine, Kelley R McCutcheon, Mayank Ghogale, Santhan Chandragiri, Deema Abayawardena, Bikram D Shrestha, Abigail Descoteaux, Kathryn Alvarez, J'nesse A Balkman and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Alexandra T LionMolecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston MA, USA.
Sophie M BodineBiology Department, Boston University, Boston MA, USA.
Kelley R McCutcheonBiology Department, Boston University, Boston MA, USA.
Mayank GhogaleBioinformatics Program, Boston University, Boston MA, USA.
Santhan ChandragiriDepartment of Physics, University of Miami, Coral Gables FL, USA.
Deema AbayawardenaDepartment of Biology, University of Miami, Coral Gables FL, USA.
Bikram D ShresthaDepartment of Physics, University of Miami, Coral Gables FL, USA.
Abigail DescoteauxMolecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston MA, USA.
Kathryn AlvarezDepartment of Physics, University of Miami, Coral Gables FL, USA.
J'nesse A BalkmanDepartment of Physics, University of Miami, Coral Gables FL, USA.
Breelyn CockeDepartment of Physics, University of Miami, Coral Gables FL, USA.
Athula H WikramanayakeDepartment of Biology, University of Miami, Coral Gables FL, USA.
Jennifer SchlezingerEnvironmental Health, Boston University, Boston MA, USA.ORCID 0000-0001-6834-4369
Joyce Y WongDepartment of Biomedical Engineering, Boston University, Boston MA, USA.
Vivek N PrakashDepartment of Physics, University of Miami, Coral Gables FL, USA.ORCID 0000-0003-4569-6462
Cynthia A BradhamMolecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston MA, USA.ORCID 0000-0001-8309-5807

Funding

Predoctoral Training in Bioinformatics and Computational BiologyT32GM100842 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI TULLIUS, THOMAS D · 2012 to 2022
$2.8M
Spatiotemporal Regulation of Developmental Pattern FormationR35GM152180 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CYNTHIA A BRADHAM · 2024 to 2026
$1.3M
NIGMS NIH HHS R35 GM152180NIGMS NIH HHS T32 GM100842
6 · The paper itself

Abstract

Per-and polyfluorinated substances (PFAS) are synthetic chemicals that are used to make fluoropolymer coatings found in many products, such as non-stick pans, clothing, cosmetics, and food packaging. These highly persistent molecules are known as "forever chemicals" since they neither degrade environmentally nor break down enzymatically within biological systems. PFAS compounds readily contaminate water sources, and as a result, certain PFAS molecules have bioaccumulated in exposed species including humans. The purpose of this study was to define the effect of two PFAS molecules, the ostensibly more toxic perfluorooctanoic acid (PFOA) and the more recent, reportedly safer chemical hexafluoropropylene oxide dimer acid (Gen X), on the development of

Indexed as

ciliaGen XneuralPFOAteratogen

Identifiers

PMID39605628
PMCPMC11601578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.