Evidence map›Paper›PMID 39605619›Full record

ArticlebioRxiv : the preprint server for biology2024

Evolutionary consequences of domestication on the selective effects of new amino acid changing mutations in canids.

Carlos Eduardo G Amorim, Chenlu Di, Meixi Lin, Clare Marsden, Christina A Del Carpio, Jonathan C Mah, Jacqueline Robinson, Bernard Y Kim, Jazlyn A Mooney, Omar E Cornejo and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carlos Eduardo G AmorimBiology Department, California State University, Northridge, California, 91330, USA.
Chenlu DiDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California, 90095, USA.
Meixi LinDepartment of Integrative Biology, University of California, Berkeley, Berkeley, California, 94720, USA.
Clare MarsdenDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California, 90095, USA.
Christina A Del CarpioDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California, 90095, USA.
Jonathan C MahDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California, 90095, USA.ORCID 0000-0003-3027-3141
Jacqueline RobinsonInstitute for Human Genetics, University of California San Francisco, San Francisco CA 94143.ORCID 0000-0002-5556-815X
Bernard Y KimDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA.
Jazlyn A MooneyDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, California, 90089, USA.ORCID 0000-0002-2369-0855
Omar E CornejoEcology & Evolutionary Biology Department, University of California, Santa Cruz, California, 95060, USA.
Kirk E LohmuellerDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California, 90095, USA.

Funding

Population genomics of the selective effects of new mutationsR35GM119856 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOHMUELLER, KIRK · 2016 to 2025
$3.4M
Characterizing Human-Pathogen Interactions and Natural Selection with Ancient DNAR35GM142939 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI GUERRA AMORIM, CARLOS EDUARDO · 2021 to 2025
$1.8M
NIGMS NIH HHS R35 GM119856NIGMS NIH HHS R35 GM142939
6 · The paper itself

Abstract

The domestication of wild canids led to dogs no longer living in the wild but instead residing alongside humans. Extreme changes in behavior and diet associated with domestication may have led to the relaxation of the selective pressure on traits that may be less important in the domesticated context. Thus, here we hypothesize that strongly deleterious mutations may have become less deleterious in domesticated populations. We test this hypothesis by estimating the distribution of fitness effects (DFE) for new amino acid changing mutations using whole-genome sequence data from 24 gray wolves and 61 breed dogs. We find that the DFE is strikingly similar across canids, with 26-28% of new amino acid changing mutations being neutral/nearly neutral (|

Identifiers

PMID39605619
PMCPMC11601280

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.