Evidence map›Paper›PMID 39605600›Full record

ArticlebioRxiv : the preprint server for biology2024

Design of facilitated dissociation enables control over cytokine signaling duration.

Adam J Broerman, Christoph Pollmann, Mauriz A Lichtenstein, Mark D Jackson, Maxx H Tessmer, Won Hee Ryu, Mohamad H Abedi, Danny D Sahtoe, Aza Allen, Alex Kang and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Adam J BroermanInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6878-1769
Christoph PollmannDepartment of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.ORCID 0000-0002-1473-0288
Mauriz A LichtensteinInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Mark D JacksonDepartment of Chemistry, University of Washington, Seattle, WA, USA.
Maxx H TessmerDepartment of Chemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6357-3496
Won Hee RyuDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.
Mohamad H AbediInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9717-6288
Danny D SahtoeInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9095-0744
Aza AllenInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8053-9070
Alex KangInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5487-0499
Joshmyn De La CruzInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Evans BrackenbroughInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0009-0004-1476-0219
Banumathi SankaranMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Asim K BeraInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9473-2912
Daniel M ZuckermanDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0001-7662-2031
Stefan StollDepartment of Chemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4255-9550
Florian PraetoriusInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0002-0806-8101
Jacob PiehlerDepartment of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany.ORCID 0000-0002-2143-2270
David BakerInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7896-6217

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6M
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
WESTPA: A high-performance framework for simulating at the frontiers of biologyR01GM115805 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LILLIAN T CHONG · 2015 to 2026
$4.0M
De Novo Design of Minibinder Antagonists for COVID-19 and Future PandemicsR01AI160052 · NIAID · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID, FULLER, DEBORAH H. · 2021 to 2025
$3.5M
Equipment Supplement: DEER spectroscopy tools for probing protein conformational dynamicsR35GM151956 · NIGMS · UNIVERSITY OF WASHINGTON · PI Stefan Stoll · 2024 to 2026
$1.4M
High-sensitivity upgrade of DEER/EPR spectrometerS10OD021557 · OD · UNIVERSITY OF WASHINGTON · PI STOLL, STEFAN · 2017 to 2017
$495k
NIAID NIH HHS R01 AI160052NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM133893NIGMS NIH HHS R01 GM115805NIGMS NIH HHS R35 GM151956NIH HHS S10 OD021557
6 · The paper itself

Abstract

Protein design has focused primarily on the design of ground states, ensuring they are sufficiently low energy to be highly populated

Identifiers

PMID39605600
PMCPMC11601400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.