Evidence map›Paper›PMID 39605577›Full record

ArticlebioRxiv : the preprint server for biology2024

Laminin β4 is required for the development of human peripheral sensory neurons.

Kenyi Saito-Diaz, Tripti Saini, Archie Jayesh Patel, Christina James, Kimata Safi Thomas, Trinity Nora Knight, Stephanie Beatrice Gogita, Nadja Zeltner

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Kenyi Saito-DiazCenter for Molecular Medicine, University of Georgia, Athens GA, USA.
Tripti SainiCenter for Molecular Medicine, University of Georgia, Athens GA, USA.
Archie Jayesh PatelCenter for Molecular Medicine, University of Georgia, Athens GA, USA.
Christina JamesCenter for Molecular Medicine, University of Georgia, Athens GA, USA.
Kimata Safi ThomasCenter for Molecular Medicine, University of Georgia, Athens GA, USA.
Trinity Nora KnightCenter for Molecular Medicine, University of Georgia, Athens GA, USA.
Stephanie Beatrice GogitaCenter for Molecular Medicine, University of Georgia, Athens GA, USA.
Nadja ZeltnerCenter for Molecular Medicine, University of Georgia, Athens GA, USA.

Funding

Precision Medicine for the Peripheral Nervous System Disorder Familiar DysautonomiaR01NS114567 · NINDS · UNIVERSITY OF GEORGIA · PI Nadja Zeltner · 2021 to 2026
$3.0M
NINDS NIH HHS R01 NS114567
6 · The paper itself

Abstract

The extracellular matrix (ECM) is a mixture of glycoproteins and fibrous proteins that provide the biophysical properties necessary to maintain cellular homeostasis. ECM integrity is of particular importance during development, where it allows proper migration and cellular differentiation. Laminins are ECM heterotrimeric proteins consisting of α, β, and γ chains. There are five known α chains, four β chains, and three γ chains. Thus, there are 60 potential combinations for laminin trimers, however only 16 laminin trimers have been identified to date. Furthermore, none of them contain laminin β4 and its function is unknown. Here, we sought to characterize the role of

Identifiers

PMID39605577
PMCPMC11601542

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.