Evidence map›Paper›PMID 39605571›Full record

ArticlebioRxiv : the preprint server for biology2024

The role of secondary structures of peptide polymers on antimicrobial efficacy and antibiotic potentiation.

Swagatam Barman, Alimi Abiodun, Md Waliullah Hossain, Adam Parris, Aiswarya Banshidhar Chandrasseril, Ethan A Older, Jie Li, Alan W Decho, Chuanbing Tang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Swagatam BarmanDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Alimi AbiodunDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Md Waliullah HossainDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Adam ParrisDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Aiswarya Banshidhar ChandrasserilDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Ethan A OlderDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Jie LiDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.ORCID 0000-0001-7977-6749
Alan W DechoDepartment of Environmental Health Sciences, University of South Carolina, Columbia, South Carolina 29208, United States.
Chuanbing TangDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.ORCID 0000-0002-0242-8241

Funding

Microscopy and Flow Cytometry CoreP30GM154632 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Hippokratis Kiaris · 2024 to 2026
$4.5M
Control of Facial Amphiphilicity to Tune Macromolecular Interactions with BacteriaR01AI149810 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TANG, CHUANBING · 2020 to 2024
$1.8M
NIAID NIH HHS R01 AI149810NIGMS NIH HHS P30 GM154632
6 · The paper itself

Abstract

The rise of antibiotic resistance, biofilm formation, and dormant bacterial populations poses serious global health threats. Synthetic antimicrobial peptide (AMP) mimics offer promising alternatives, though the impact of secondary structures in polymeric AMP mimics on antimicrobial efficacy is underexplored. This study investigates chirality-controlled α-peptide polymers (D-PP and DL-PP), synthesized via ring-opening polymerization of allylglycine

Identifiers

PMID39605571
PMCPMC11601527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.